Search for dissertations about: "alternative splice"
Showing result 21 - 25 of 75 swedish dissertations containing the words alternative splice.
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21. Human α2,3-sialyltransferases. Structure and Function of Alternatively Spliced Transcripts
Abstract : The recruitment of human peripheral blood leukocytes to sites of infection and inflammation requires the surface expression of Sialyl Lewis x glycoconjugates (SLex) on white blood cells and their interaction with E- and P-selectins on activated endothelial cells. Human ST3Gal III, ST3Gal IV and ST3Gal VI genes code for a2,3?sialyltransferases potentially involved in the biosynthesis of the SLex epitope. READ MORE
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22. Application of Fracture Mechanics to Concrete Bridges. Finite element analyses and experiments
Abstract : Material models based on fracture mechanics together with non-linear finite element analyses have been used in combination with experiments to study the behaviour of reinforced concrete bridges. The work covers two aspects of interest in the design of concrete bridges.* The shear behaviour was studied in full-scale tests on two highway bridges. READ MORE
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23. On the Evolution of Reproductive Systems in Neurospora
Abstract : The aim of this thesis was to study the evolution of reproductive systems and reproductive traits in the fungal genus Neurospora. More specifically, I have investigated the evolutionary forces shaping the genes involved in sexual reproduction, focusing on mating-type (mat) and pheromone receptor (pre) genes. READ MORE
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24. Molecular Mechanisms of Frontotemporal Lobar Degeneration
Abstract : The aim of this thesis was to identify genetic factors involved in frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder clinically characterised by a progressive change in personality, behaviour and language. FTLD is a genetically complex disorder and a positive family history is found in up to 40% of the cases. READ MORE
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25. p53 inactivation by point mutations and splice site mutations in human and mouse tumors
Abstract : The p53 tumor suppressor gene is frequently mutated in human tumors. p53 induces cell cycle arrest and/or apoptosis in response to cellular stress, such as DNA damage, hypoxia and certain activated oncogenes like c-myc. The status of p53 in Burkitt's Iymphoma (BL) cell lines was investigated. The majority of BL lines expressed mutated p53 protein. READ MORE