Search for dissertations about: "alzheimer disease treatment"

Showing result 1 - 5 of 43 swedish dissertations containing the words alzheimer disease treatment.

2. 1. Allergy and Alzheimer disease

   Author : Heela Sarlus; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Alzheimer disease (AD) is a neurodegenerative disorder characterized by progressive dementia with devastating effects for the patients and their families. The treatments available are purely symptomatic and there is need for treatment strategies aiming at the etiopathogenesis of AD. READ MORE

4. 2. Long-term treatment response, predictors and biochemical markers in Alzheimer’s disease

   Author : Åsa Wallin; Klinisk minnesforskning; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; treatment response; cholinesterase inhibitor; CSF-biomarkers; pre-treatment progression; predictors; Alzheimer’s disease;

   Abstract : Alzheimer’s disease (AD) is clinically characterised by an insidious onset with progressive symptoms of memory impairment, dysphasia, dyspraxia, dygnosia and visuospatial difficulties. Degeneration of neurons in specific regions of the brain, formation of senile plaques and neurofibrillary changes are some of the neuropathological features of the disease. READ MORE

5. 3. Statin treatment and beta-Amyloid Production in Patients with Alzheimer s Disease

   Author : Kina Höglund; Göteborgs universitet; []
   Keywords : Alzheimer s disease; amyloid precursor protein; beta-amyloid; cholesterol; statins; CSF;

   Abstract : Alzheimer s disease (AD) is a progressive neurodegenerative disorder pathologically characterized by neurofibrillary tangles and amyloid plaques. According to the amyloid cascade hypothesis, the increased production of beta-amyloid (Abeta), derived form the amyloid precursor protein (APP), and its aggregation into plaques are key pathological events, driving neurodegeneration in AD. READ MORE

6. 4. Amyloid-β Protofibrils in Alzheimer´s Disease : Focus on Antibodies, Inflammation and Astrocytes

   Author : Sofia Söllvander; Lars Lannfelt; Anna Erlandsson; Frida Ekholm-Pettersson; Linda Söderberg; Pär Gellerfors; Martin Hallbeck; Uppsala universitet; []
   Keywords : Alzheimer s Disease; Amyloid-beta; Protofibrils; ELISA; ELISpot; Astrocyte; Monoclonal Antibody; Immunofluorescence; Medicinsk vetenskap; Medical Science;

   Abstract : Soluble amyloid-beta (Aβ) aggregates, including Aβ protofibrils, play a central role in Alzheimer’s disease (AD) and constitute a potential diagnostic biomarker and a therapeutic target. Aβ protofibrils promote synapse dysfunction and neurodegeneration, but the mechanisms behind these effects remain unclear. READ MORE

7. 5. Alzheimer disease : subcellular Aβ mechanisms and treatment strategies

   Author : Yang Gao; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The amyloid β-peptide (Aβ) is the key molecule in the pathogenesis of Alzheimer disease (AD), but the mechanisms of its toxicity are still largely unknown. This thesis includes studies aimed at studying Aβ induced mechanisms in neurons at the subcellular level and explore effective AD treatment strategies. READ MORE