Search for dissertations about: "alzheimer golgi"

Found 5 swedish dissertations containing the words alzheimer golgi.

  2. 1. Intracellular dynamics of Alzheimer disease-related proteins

    Author : Alexandra Selivanova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer’s disease is a devastating neurodegenerative disorder characterized by accumulation of amyloid-β peptide and formation of amyloid plaques and aggregates of hyperphosphorylated tau protein forming neurofibrillary tangles. The amyloid-β peptide is generated through sequential processing of the amyloid precursor protein (APP) by β- and γ-secretase. READ MORE

  4. 2. Alzheimer disease : studies on Abeta and gamma-secretase in human brain

    Author : Hedvig Welander; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer disease (AD) is a devastating neurodegenerative disorder and the most prevalent form of dementia. One hallmark of the disease is the extracellular deposition of amyloid beta-peptide (Abeta) into senile plaques in the brain. Biochemical and genetic studies reveal Abeta as a key player in AD pathogenesis. READ MORE

  5. 3. The role of mTor in the pathogenesis of tau-related pathologies in Alzheimer disease

    Author : Zhi Tang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : An important neurophathological hallmark of Alzheimer disease (AD) is the progressive formation of neurofibrillary tangles composed of aberrant hyperphosphorylated tau aggregates. Evidence from human postmortem AD brains and in vitro and in vivo rapamycin-treated drug models implicated an abnormal accumulation of the mammalian target of rapamycin (mTor) in AD brains. READ MORE

  6. 4. Lysosomal Involvement in the Pathogenesis of Alzheimer's Disease

    Author : Lin Zheng; Jan Marcusson; Alexei Terman; Martin Hallbeck; Lars Nilsson; Linköpings universitet; []
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    Abstract : Alzheimer’s disease (AD), the major cause of senile dementia, is associated with progressive formation of neurofibrillary tangles and extraneuronal plaques composed of amyloid beta peptide (Aβ). Aβ has been also found within Alzheimer neurons in association with the lysosomal system, an acidic vacuolar compartment possessing numerous hydrolytic enzymes. READ MORE

  7. 5. Studies on gamma-secretase activity and products

    Author : Jenny Frånberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : gamma-Secretase is a transmembrane aspartyl protease involved in processing of a multitude of functionally diverse substrates within their transmembrane domains. gamma-Secretase cleavage of the amyloid precursor protein (APP) generates the APP intracellular domain (AICD) and the amyloid beta-peptide (Abeta). READ MORE