Search for dissertations about: "amino acid transporter"

Showing result 1 - 5 of 41 swedish dissertations containing the words amino acid transporter.

  2. 1. Characterization of Amino Acid Transporters : Transporters expressed in the central nervous system belonging to the Solute Carrier family SLC38

    Author : Sofie Victoria Hellsten; Robert Fredriksson; Gether Ulrik; Uppsala universitet; []
    Keywords : Solute carriers; amino acid transporter; SLC38 family; SLC38A8; SNAT8; SLC38A10; SNAT10; SLC38A9; SNAT9; amino acid starvation; AAR; mTORC1; Neuroscience; Neurovetenskap;

    Abstract : In cells and organelles transporters are responsible for translocation of amino acids, sugars and nucleotides among others. In the central nervous system (CNS), amino acid transporters can function as neurotransmitter transporters and nutrient sensors. READ MORE

  4. 2. Characterization of Amino Acid Transporters in the Brain : Molecular and Functional Studies of Members within the Solute Carrier Families SLC38 and SLC6

    Author : Maria Hägglund; Robert Fredriksson; Farrukh Chaudhry; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amino acid transporter; Solute Carrier; Glutamine; Leucine; SNAT; B0AT; Neuroscience; Neurovetenskap;

    Abstract : Solute carriers (SLCs) comprise the largest group of transporters in humans and there are currently 52 SLC families. They are embedded in cellular membranes and transport numerous molecules; defects in many of the genes encoding SLCs have been connected to pathological conditions, and several SLCs are potential drug targets. READ MORE

  5. 3. The Biological Importance of the Amino Acid Transporter SLC38A10 : Characterization of a Knockout Mouse

    Author : Frida A. Lindberg; Robert Fredriksson; Erika Roman; Karin Nordenankar; Vootele Vöikar; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Solute carrier; SLC; SNAT10; SLC38A10; phenotyping; behavior; amino acids; knockout mouse model; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The biggest group of transporters, the solute carriers (SLCs), has more than 400 members, and about 30% of these are still orphan. In order to decipher their biological function and possible role in disease, there is a need for characterization of these. READ MORE

  6. 4. Unlocking the Role Of Orphan Solute Carrier SLC38A10 In Brain Metabolism : The SLC38A10 transporter in nutrient and metabolic regulation

    Author : Rekha Tripathi; Robert Fredriksson; Manuel Palacín; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Solute carrier; SLC38A10 transporter; SLC38 family; ER Golgi localization; Amino acid starvation; Nutrient sensing; mTOR signaling; Transcriptomic; Protein array; Metabolomics; Ingenuity Pathway Analysis; Farmaceutisk vetenskap; Pharmaceutical Science; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Membrane transporters are the primary gatekeepers of cells and regulate the transport of nutrients, metabolites, ions, water, and neurotransmitters into and across the human cells. The solute carrier transporters (SLCs) are the most prominent transporters, comprising 430 members divided into 65 subfamilies. READ MORE

  7. 5. Solute Carriers in Metabolism : Regulation of known and putative solute carriers in the central nervous system

    Author : Emilia Lekholm; Robert Fredriksson; Helgi B. Schiöth; David Drew; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Solute Carriers; transporter; amino acid starvation; glucose metabolism; MFS; SV2; Medical Science; Medicinsk vetenskap;

    Abstract : Solute carriers (SLCs) are membrane-bound transporter proteins, important for nutrient, ion, drug and metabolite transport across membranes. A quarter of the human genome codes for membrane-bound proteins, and SLCs make up the largest group of transporter proteins. READ MORE