Search for dissertations about: "aminoglycosides resistance thesis"

Showing result 1 - 5 of 11 swedish dissertations containing the words aminoglycosides resistance thesis.

  2. 1. Antibiotic Resistance and the Cellular Currency S-adenosyl-methionine : Modification of aminoglycosides and nucleic acids

    Author : Sandesh Kanchugal P; Maria Selmer; Ditlev Brodersen; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antibiotic resistance; streptomycin; spectinomycin; X-ray crystallography; methyltransferase; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : Streptomycin and spectinomycin are antibiotics that bind to ribosomes and inhibit protein synthesis. Common resistance mechanisms involve enzymatic modification of the two drugs by aminoglycoside nucleotidyltransferases (ANTs). The first part of this thesis covers the structural mechanism of two ANT enzymes. READ MORE

  4. 2. Antibiotic Resistance in Wastewater : Methicillin-resistant Staphylococcus aureus (MRSA)and antibiotic resistance genes

    Author : Stefan Börjesson; Per-Eric Lindgren; Johanna Ericson Sollid; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MRSA; SCCmec; spa typing; Staphylococcus aureus; methicillin; B-lactam; aminoglycoside; tetracycline; antibiotic; wastewater; wastewater treatment plant; Microbiology; Mikrobiologi;

    Abstract : A large part of the antibiotics consumed ends up in wastewater, and in the wastewater the antibiotics may exert selective pressure for or maintain resistance among microorganisms. Antibiotic resistant bacteria and genes encoding antibiotic resistance are commonly detected in wastewater, often at higher rates and concentrations compared to surface water. READ MORE

  5. 3. Structural and Biochemical Studies of Antibiotic Resistance and Ribosomal Frameshifting

    Author : Yang Chen; Maria Selmer; Dominique Fourmy; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein synthesis; elongation; elongation factor G; fusidic acid; antibiotic resistance; aminoglycoside adenyltransferase; ribosomal frameshifting; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Abstract : Protein synthesis, translation, performed by the ribosome, is a fundamental process of life and one of the main targets of antibacterial drugs. This thesis provides structural and biochemical understanding of three aspects of bacterial translation.Elongation factor G (EF-G) is the target for the antibiotic fusidic acid (FA). READ MORE

  6. 4. On Fusidic Acid Resistance in Staphylococcus Aureus

    Author : Tobias Norström; Diarmaid P. Hughes; Bruce R. Levin; Uppsala universitet; []
    Keywords : Microbiology; S. aureus; SCV; fusidic acid; FusE; Mikrobiologi;

    Abstract : Controlling bacterial infections with antibiotics is central to modern health care. However, increasing bacterial resistance to antibiotics threatens effective therapy. This thesis concerns the use of the antibiotic fusidic acid, and novel analogues of fusidic acid, to treat topical infections caused by the bacterial pathogen Staphylococcu aureus. READ MORE

  7. 5. Chromosomal antibiotic resistance mechanisms in Pseudomonas aeruginosa and Neisseria gonorrhoeae

    Author : Sohidul Islam; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The progressive increase in fluoroquinolone resistant N. gonorrhoeae and emergence of multiple antibiotic resistant P. aeruginosa are growing concerns among physicians and health policy makers. In N. READ MORE