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Showing result 1 - 5 of 27 swedish dissertations matching the above criteria.

  2. 1. Regulation of Mammalian Poly(A) Polymerase Activity

    Author : Ann-Charlotte Thuresson; Barklie Clements; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; poly A polymerase; PAP; polyadenylation; isoforms; phosphorylation; alternative splicing; CPSF interaction; aminoglycosides; Biomedicin; Microbiology; Mikrobiologi; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Poly(A) polymerase (PAP) is the enzyme catalyzing the synthesis of the adenine tail to the 3’-end of mRNA. This A-tail is present on the majority of the primary RNA transcripts of protein-coding genes, and is important for mRNA stability, export to the cytoplasm and translation. Therefore, PAP is a key regulator of eukaryotic gene expression. READ MORE

  4. 2. Pharmacokinetics and pharmacodynamics of aminoglycosides

    Author : Barbro Isacsson; Stig Holm; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : The pharmacokinetics of amikacin in humans and the pharmacodynamic effects, i.e. initial killing and postantibiotic effect (P AE), of the aminoglycosides were studied in this thesis. READ MORE

  5. 3. Applications of organ culture of the mouse inner ear

    Author : Diana Berggren; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; organ culture; embryonic inner ear; intercellular junctions; aminoglycosides; statoacoustic ganglion; intermediate filaments; collagen; endolymph;

    Abstract : The embryonic mouse inner ear was used as a model with which to study ototoxicity and tissue interactions. The inner ear anlage can be explanted and cultured in vitro from about the 12th gestational day (gd), and will differentiate parallel with the inner ear developing in vivo until a time corresponding to birth (21st gd). READ MORE

  6. 4. Tracking single molecules in uncharted territory : A single-molecule method to study kinetics in live bacteria

    Author : Javier Aguirre Rivera; Magnus Johansson; Dmitri N. Ermolenko; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; single-molecule; protein synthesis; fluorescence microscopy; antibiotics; aminoglycosides; macrolides; apramycin; gentamicin; paromomycin; S13; translation; bacteria; Molekylär biovetenskap; Molecular Life Sciences;

    Abstract : The synthesis of proteins, also known as translation, is a fundamental process in every living organism. The steps in the translation of genetic information to functional proteins have been meticulously studied, mostly using in vitro techniques, yielding a detailed model of their mechanisms. READ MORE

  7. 5. Antibiotic-induced Bacterial Toxin Release – Inhibition by Protein Synthesis Inhibitors

    Author : Gunilla Hjerdt-Goscinski; Jan Sjölin; Monica Lundholm; Inga Odenholt; Ingrid Nilsson-Ehle; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Communicable diseases; Endotoxin; LPS; exotoxin; SpeA; penicillin-binding protein; aminoglycosides; clindamycin; β-lactam antibiotics; severe sepsis; septic shock; Infektionssjukdomar; Infectious diseases; Infektionssjukdomar;

    Abstract : Toxic products, such as endotoxin from the gram-negative and exotoxin from the gram-positive bacteria, are the most important initiators of the inflammatory host response in sepsis. In addition to antibacterial treatment, numerous attempts have been made to interfere with the exaggerated proinflammatory cascade initiated by the toxins. READ MORE