Search for dissertations about: "amiodarone"

Showing result 1 - 5 of 9 swedish dissertations containing the word amiodarone.

  1. 1. Molecular pharmacology of amiodarone

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine

    Author : Viktor Drvota; Karolinska Institutet.; Karolinska Institutet.; [1997]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amiodarone; thyroid hormone receptors; B-adrenergic receptors; AT-1 cardiomyocytes; Western blot; solution hybridization; Fura-2; Langendorff heart; mouse; guinea pig;

    Abstract : MOLECULAR PHARMACOLOGY OF AMIODARONE Amiodarone (Am) is a potent class III antiarrhythmic drug. Its use is limited due to serious side effects and it was therefore used only when other therapeutic interventions proved to be ineffective. READ MORE

  2. 2. Novel Interventions in Cardiac Arrest Targeted Temperature Management, Methylene Blue, S-PBN, Amiodarone, Milrinone and Esmolol,  Endothelin and Nitric Oxide In Porcine Resuscitation Models

    University dissertation from Uppsala : Uppsala universitet

    Author : Frank Zoerner; Uppsala universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; restoration of spontaneous circulation; ROSC; cardiopulmonary resuscitation; CPR; cardiac arrest; methylene blue; MB; S-PBN; mild therapeutic hypothermia; MTH; targeted temperature management; TTM; endothelin; ET-1; ECE-1; ETAR; ETBR; nitric oxide; NO; nitric oxide synthase; NOS; eNOS; iNOS; nNOS; porcine; amiodarone; hypovolemia; milrinone; vasopressin; esmolol; epinephrine; Anaesthesiology and Intensive Care; Anestesiologi och intensivvård; Medical Cell Biology; Medicinsk cellbiologi; Kardiologi; Cardiology;

    Abstract : It is a major clinical problem that survival rates after out-of-hospital cardiac arrest have not markedly improved during the last decades, despite extensive research and the introduction of new interventions. However, recent studies have demonstrated promising treatments such as targeted temperature management (TTM) and methylene blue (MB). READ MORE

  3. 3. In vitro studies on the mechanisms of inhibited thyroidal iodide uptake and destructive thyroiditis as adverse effects of amiodarone and interferon-gamma

    University dissertation from Uppsala : Uppsala universitet

    Author : Sofia Tedelind; Göteborgs universitet.; Gothenburg University.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; thyroid; amiodarone; interferon-gamma; iodide transport; tight junction; mitochondria; endocytosis;

    Abstract : The clinical use of the potent anti-arrhythmic drug amiodarone is limited due to adverse effects e.g. in the thyroid comprising both hypo- and hyperthyroidism. Amiodarone-induced thyroid dysfunction can occur in subjects with normal thyroid glands but also in those with an underlying thyroid abnormality resulting in an aggravation of the condition. READ MORE

  4. 4. Real-Time Monitoring of Healthcare Interventions in Routine Care Effectiveness and Safety of Newly Introduced Medicines

    University dissertation from Uppsala : Uppsala University

    Author : Thomas Cars; Uppsala universitet.; [2016]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Electronic Health Records; Comparative Effectiveness Research; Comparative Safety Research; Sequential drug monitoring; propensity score; real-world data; infliximab; TNF-inhibitors; dronedarone; amiodarone; flecainide; Farmakoepidemiologi; Pharmacoepidemiology;

    Abstract : Before market authorization of new medicines, their efficacy and safety are evaluated using randomized controlled trials. While there is no doubt about the scientific value of randomized trials, they are usually conducted in selected populations with questionable generalizability to routine care. READ MORE

  5. 5. Thyroid hormone receptor expression in cardiovascular disease and pharmacology

    University dissertation from Stockholm : Karolinska Institutet, Department of Medicine at Huddinge University Hospital

    Author : Shiva Shahrara; Karolinska Institutet.; Karolinska Institutet.; [1999]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TR mRNA; amiodarone; propranolol; heart rate; Quantitative RT-PCR; Western blot; Northern blot; mRNA and protein distribution; chronic valvular disease; Mated cardiomyopathy; AT- I cardiomyocytes; mouse myocardium;

    Abstract : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. READ MORE