Search for dissertations about: "amiodarone"

Showing result 6 - 10 of 10 swedish dissertations containing the word amiodarone.

  2. 6. Studies on malignant ventricular tachyarrhythmias and their treatment with an implantable defibrillator

    Author : Bengt Sandstedt; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Implantable cardioverter defibrillator; ventricular fibrillation; ventricular tachycardia; predischarge test; defibrillation threshold; discrimination; electrogram morphology; aortic stenosis; hypertrophy; noradrenalin;

    Abstract : Aims: To investigate the hemodynamic, metabolic and autonomic effects of ventricular fibrillation per se during maintained circulation. To study the defibrillation threshold (DFT) and efficacy of a new and thinner ICD lead (DSP) compared with the standard lead (C). READ MORE

  4. 7. Prevalence of drug-drug interactions and clinical relevance for treatment with oral anticoagulants

    Author : Johan Holm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this thesis was to describe prevalences and frequencies of potential DDIs in the Swedish outpatient population, and the clinical effects in treatment with oral anticoagulants. Two cross-sectional studies were conducted to establish the prevalence and frequency of potential DDIs among Swedish outpatients. READ MORE

  5. 8. On the Prediction of Warfarin Dose

    Author : Niclas Eriksson; Mia Wadelius; Lars Wallentin; Lars Berglund; Patrik Magnusson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Warfarin; pharmacogenetics; prediction models; Dosing algorithm; GWAS; VKORC1; CYP2C9; Clinical Pharmacology; Klinisk farmakologi;

    Abstract : Warfarin is one of the most widely used anticoagulants in the world. Treatment is complicated by a large inter-individual variation in the dose needed to reach adequate levels of anticoagulation i.e. INR 2. READ MORE

  6. 9. Antiarrhythmic and arrhythmic effects of an Ikr-blocking class III agent. A clinical and electrocardiographic study of almokalant

    Author : Birgitta Houltz; Göteborgs universitet; []
    Keywords : Almokalant; class III antiarrhythmic agent; potassium channel blocker; atrial fibrillation; sinus rhythm; conversion; electrocardiographic; QT interval prolongation; T wave morphology; prediction; torsades de pointes; proarrhythmia; QT dispersion; ventric;

    Abstract : The interest in class III drugs has increased over the last decades as being potent antiarrhythmic agents in their mode of action by prolongation of repolarization and with no effect on conduction. Class I antiarrhythmic agents have proven effective in conversion of atrial fibrillation (AF), but may cause serious proarrhythmia. READ MORE

  7. 10. Improving assessment of cardiovascular arrhythmic safety of new pharmacologic agents

    Author : Lars Johannesen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Fourteen drugs have been removed from the market worldwide due to an increased risk of torsade de pointes (TdP), a potentially fatal ventricular arrhythmia. Almost all of the removed drugs that have been linked to an increased risk for TdP have been shown to block the human ether-à-go-go-related gene (hERG) potassium channel. READ MORE