Search for dissertations about: "amorphous drugs"

Showing result 1 - 5 of 15 swedish dissertations containing the words amorphous drugs.

  2. 1. Amorphous magnesium carbonate nanomaterials : Synthesis, characterization and applications

    Author : Jiaojiao Yang; Ken Welch; Mika Lindén; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; high surface-to-volume ratio; nanoparticles; mesoporous; magnesium carbonate; amorphous drugs; supersaturated concentration; general adhesives; UV-shielding;

    Abstract : High surface-to-volume ratio materials, including nanoparticles and mesoporous materials, have a number of applications due to their large surface area and special structures. Traditional approaches for synthesizing high surface-to-volume ratio nanomaterials are often complicated, expensive or environmentally unfriendly. READ MORE

  4. 2. Pharmaceutical Nanocomposites : Structure–Mobility–Functionality Relationships in the Amorphous State

    Author : Joel Hellrup; Denny Mahlin; Göran Alderborn; László Fábián; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amorphous; pharmaceutical composites; solid state; structure; molecular mobility; spray-drying; freeze-drying; moisture sorption; physical stability; compression; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Amorphous materials are found in pharmaceutical formulations both as excipients and active ingredients. Indeed, these formulations are becoming an essential strategy for incorporating drugs into well-performing solid dosage forms. READ MORE

  5. 3. Porous Amorphous Calcium Carbonate and Phosphate : Synthesis and Application

    Author : Rui Sun; Ocean Cheung; Maria Strømme; Ken Welch; Denis Gebauer; Uppsala universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; amorphous calcium carbonate; amorphous calcium phosphate; stabilization; crystallization; porous material; drug delivery; gas adsorption; Engineering Science with specialization in Nanotechnology and Functional Materials; Teknisk fysik med inriktning mot nanoteknologi och funktionella material;

    Abstract : The synthesis of porous amorphous calcium carbonate (ACC) and porous amorphous calcium phosphate (ACP) was developed in this thesis. Porous ACC with specific Brunauer–Emmett–Teller (BET) surface area of >350 m2/g was synthesized using a surfactant free approach. The high surface area of porous ACC was related to its nanostructure. READ MORE

  6. 4. Molecular Mechanisms Influencing the Performance of Amorphous Formulations for Poorly Water-Soluble Drugs

    Author : Khadijah Edueng; Christel Bergström; Denny Mahlin; Michael Hageman; Uppsala universitet; []
    Keywords : Amorphous formulation; crystallisation; supersaturation; glass-forming ability; physical stability; glass stability; spray-dried solid dispersion; dissolution; promiscuous glass former; poorly-soluble drug; solid-to-solid; solution-mediated; particle-associated; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Crystallisation is a concern for amorphous formulation because it compromises the solubility-enhancing benefit gained from amorphisation. Traditionally, amorphous formulation had been designed primarily based on trial-and-error approach. READ MORE

  7. 5. Mesoporous magnesium carbonate as a drug delivery vehicle for stabilising amorphous drugs and regulating their release rate

    Author : Peng Zhang; Maria Strømme; Niklas Hedin; Uppsala universitet; []
    Keywords : mesoporous; magnesium carbonate; drug delivery; solubility enhancement; bioavailability; pharmacokinetics; diffusion release; controlled release; Teknisk fysik med inriktning mot nanoteknologi och funktionella material; Engineering Science with specialization in Nanotechnology and Functional Materials;

    Abstract : In today’s drug discovery, the number of candidate drugs based on new molecular entities with poor aqueous solubility is increasing. Since poor aqueous solubility of an active pharmaceutical ingredients (APIs) is associated with low bioavailability and thus limite their therapeutic effect, this is often a great challenge in the development of new drugs when oral administration is the preferred route of administration. READ MORE