Search for dissertations about: "amphiphilic molecules in drug delivery"

Showing result 1 - 5 of 14 swedish dissertations containing the words amphiphilic molecules in drug delivery.

2. 1. Microgels as drug delivery vehicles : loading and release of amphiphilic drugs

   Author : Yassir Al-Tikriti; Per Hansson; Magnus Bergström; Matthew Libera; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microgel; amphiphilic drug; phase separation; micropipette; Raman microscopy; controlled release; drug delivery; SAXS; Pharmaceutical Physical Chemistry; Farmaceutisk fysikalisk kemi;

   Abstract : Polyelectrolyte microgels are used as delivery vehicles for amphiphilic drugs in, e.g., treatments of liver cancer by a method called trans-arterial chemoembolization. READ MORE

4. 2. Development and characterization of an in vitro method for interaction studies between polymers and pharmaceuticals : Aiding in the development of new drug delivery systems

   Author : Marcus Wanselius; Per Hansson; Magnus Bergström; Susanna Abrahmsén-Alami; Christian Pedersen; Anna Fureby; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microgels; Subcutaneous administration; Drug delivery; Microfluidics; In vitro methodology; Method development; Biopharmaceuticals; Amphiphilic drugs; Polyelectrolytes; Hyaluronic acid; Peptides; Farmaceutisk fysikalisk kemi; Pharmaceutical Physical Chemistry;

   Abstract : Polymers are a group of macromolecules used in formulations of pharmaceuticals, one example being the delivery system DC Bead™. Further, some of the most abundant and for drug delivery important constituents of the subcutaneous tissue are charged polymers (polyelectrolytes), e.g. collagen, hyaluronic acid, and chondroitin sulfate. READ MORE

5. 3. Environment-Sensitive Multifunctional Drug Delivery Systems

   Author : Jian Qin; Mamoun Muhammed; Marcus Textor; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Materials chemistry; Materialkemi;

   Abstract : Drug delivery systems (DDS) with multiple functionalities such as environment-sensitive drug release mechanisms and visualization agents have motivated the biomedical community as well as materials chemists for more than a decade. This dissertation is concerned with the development of nanoparticles for multifunctional DDS  to tackle several crucial challenges in these complex systems, including polymeric nanospheres which respond to temperature change, superparamagnetic iron oxide nanoparticles/polymeric composite for magnetic resonance imaging contrast agents and drug carriers, immunoresponse of nanomaterials and injectable magnetic field sensitive ferrogels. READ MORE

6. 4. In vitro evaluation of formulations used in the treatment of hepatocellular carcinoma

   Author : Emelie Ahnfelt; Hans Lennernäs; Erik Sjögren; Niklas Axén; Jesper Østergaard; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Drug delivery system; Doxorubicin; Microgel; Emulsion; Hepatocellular carcinoma; Biofarmaci; Biopharmaceutics;

   Abstract : Hepatocellular carcinoma (HCC) causes ~ 600,000 deaths annually, making it the second most deadly cancer form. HCC is classified into five stages and for the intermediate HCC treatment, the two most commonly used drug delivery systems (DDSs) are lipiodol-based emulsions and drug-eluting beads. READ MORE

7. 5. Characterization of nucleic acid delivery with fatty acid modified cell-penetrating peptide nanoparticle formulations

   Author : Tõnis Lehto; Ülo Langel; Patrick Midoux; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Transfection; gene delivery; oligonucleotide; complexes; non-viral; in vivo; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : Recent advances with techniques used for manipulating gene expression have brought us to an era where various gene therapeutic approaches are becoming common therapeutic tools for many previously incurable diseases. The main factor impeding the wider translation of gene therapy is that the active pharmaceutical ingredients used for interfering with gene expression are based on nucleic acids and synthetic oligonucleotides and such molecules do not readily reach their intracellular targets due to their physicochemical properties and therefore they require delivery vectors to cross the cell membrane. READ MORE