Search for dissertations about: "ampk"

Showing result 1 - 5 of 53 swedish dissertations containing the word ampk.

  1. 1. Dynamic control of the yeast AMPK/SNF1 pathway in response to glucose signals

    Author : Loubna Bendrioua; Göteborgs universitet.; Gothenburg University.; [2014]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; AMPK; SNF1; Mig1; glucose signalling; dynamic control; mechanism; Saccharomyces cerevisiae;

    Abstract : The SNF1/AMP-activated protein kinase (AMPK) belongs to a family of energy sensors that is conserved in all eukaryotes. Activated by ATP depletion, AMPK plays a vital role in restoring the energy balance by enhancing energy-generating and damping energy-requiring processes. READ MORE

  2. 2. Protein kinases in hormonal regulation of adipocyte metabolism

    University dissertation from Protein Phosphorylation, Faculty of Medicine

    Author : Christine Berggreen; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2014]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adipocyte; PKB; AMPK; SIK3; insulin; catecholamines; lipolysis; lipogenesis; glucose uptake; de novo fatty acid synthesis; A769662; Akti; cAMP;

    Abstract : Abstract Along with liver and muscle tissue, adipose tissue helps maintain normal levels of glucose and lipids in the blood and has a very important role when it comes to storing lipids that can provide whole-body energy. After a meal is ingested, adipocytes take up glucose from the circulation and use it as a substrate for synthesis of new fatty acids (FAs) in a process known as de novo fatty acid synthesis, as well as for synthesis of glycerol. READ MORE

  3. 3. Glucotoxicity in Insulin-Producing β-Cells

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hanna K Nyblom; Uppsala universitet.; [2007]
    Keywords : Cell biology; type 2 diabetes; SELDI-TOF MS; glucotoxicity; proteomics; insulin secretion; mitochondria; lipids; INS-1E cells; GC-MS; HR-MAS NMR; metabolomics; human islet; AMPK; AICAR; ER stress; apoptosis; Cellbiologi;

    Abstract : Background and aims: Type 2 diabetes mellitus is connected with elevated glucose levels, which cause impaired glucose-stimulated insulin secretion (GSIS) and degeneration of β-cells. Mechanisms for such glucotoxic effects were explored in the present study.Materials and methods: INS-1E cells were cultured for 5 days in 5. READ MORE

  4. 4. Cross-regulation between TGFβ/BMP Signalling and the metabolic LKB1 pathway

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Erna Raja; [2012]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; cell signalling; TGFbeta; BMP; LKB1; AMPK; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Cell signalling determines physiological responses to many cellular stimuli and environmental changes. The transforming growth factor-beta (TGFβ)/bone morphogenetic protein (BMP) signalling pathways begin by binding of ligand to the heterodimeric receptor complex, followed by activation of Smads that translocate to the nucleus to regulate transcription of genes that further mediate cellular physiology. READ MORE

  5. 5. Detecting novel effects of exercise or AMPK activation in human skeletal muscle

    University dissertation from Stockholm : Karolinska Institutet, Dept of Molecular Medicine and Surgery

    Author : David Gray Lassiter; Karolinska Institutet.; Karolinska Institutet.; [2018]

    Abstract : Cardiovascular and metabolic disorders are among the main causes of death today. Regular exercise can prevent and treat these chronic diseases. A molecule at the center of exercise adaptations in skeletal muscle is adenosine monophosphate-activated protein kinase (AMPK). READ MORE