Search for dissertations about: "ampk"

Showing result 16 - 20 of 58 swedish dissertations containing the word ampk.

  2. 16. Peroxisome proliferator-activated receptor delta : regulation of skeletal muscle metabolism

    Author : David Kitz Krämer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Peroxisome Proliferator-Activated Receptor PPAR 4 insulin sensitivity; insulin action; human skeletal muscle; primary cultured muscle cells; lipid-metabolism; glucose metabolism; AMP activated protein kinase AMPK ; Type 2 Diabetes Mellitus;

    Abstract : Peroxisome Proliferator-Activated Receptor (PPAR) δ is a nuclear transcription factor which has been implicated in the regulation of lipid metabolism in skeletal muscle. In addition to the postural and locomotive functions of skeletal muscle, this organ has a major impact role on whole body metabolism. READ MORE

  4. 17. Adrenergic stimulation of glucose uptake in brown adipocytes

    Author : Ekaterina Chernogubova; Tore Bengtsson; Barbara Cannon; Samuel Cushman; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; Fysiologi;

    Abstract : The aim of this study was to investigate adrenergically stimulated glucose uptake in brown adipose tissue (BAT) with the focus on receptor subtypes and intracellular signalling pathways. As a model system, we used primary cultured brown adipocytes. READ MORE

  5. 18. Molecular mechanisms governing contraction-induced metabolic responses and skeletal muscle reprogramming

    Author : Stephan Glund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : AMP-activated protein kinase; interleukin-6; exercise; glucose metabolism; lipid metabolism; adaptation to exercise.;

    Abstract : Physical exercise enhances skeletal muscle responsiveness to insulin and regulates metabolism by an insulin-independent mechanism. Elucidation of contraction-mediated molecular mechanisms is imperative for a better understanding of skeletal muscle metabolism and function, and may lead to the identification or validation of possible drug targets for the prevention or treatment of metabolic disorders. READ MORE

  6. 19. Molecular regulators of glucose and lipid metabolism in skeletal muscle

    Author : Sameer S Kulkarni; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Skeletal muscle is a primary site of insulin action and insulin-stimulated glucose transport and occupies a center stage in maintaining whole body glucose and lipid homeostasis. Another key feature of a healthy skeletal muscle is its ability to switch between utilization of lipids and glucose as fuel in response to feeding or fasting respectively. READ MORE

  7. 20. Skeletal muscle metabolic flexibility : the roles of AMP-activated protein kinase and calcineurin

    Author : Yun Chau Long; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Skeletal muscle; metabolism; glucose; lipid; gene expression; AMP-activated protein kinase; calcineurin; exercise;

    Abstract : Skeletal muscle fibers differ considerably in their metabolic and physiological properties. The metabolic properties of skeletal muscle display a high degree of flexibility which adapts to various physiological demands by shifting energy substrate metabolism. READ MORE