Search for dissertations about: "amyloid angiopathy"

Showing result 1 - 5 of 9 swedish dissertations containing the words amyloid angiopathy.

  2. 1. Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy

    Author : Gustav Östner; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cystatin C; amyloid; amyloidosis; oligomers; domain swapping;

    Abstract : The pathophysiological process in Alzheimer’s disease and other amyloid disorders usually involves the transformation of a soluble monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their instability and dynamic equilibrium with smaller and larger species. READ MORE

  4. 2. Revealing the complex nature of amyloid beta and its relation to dementia

    Author : Eleni Gkanatsiou; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s Disease; Amyloid beta; Mass spectrometry; Cerebral amyloid angiopathy; Down Syndrome; Pathological ageing; Dementia with Lewy bodies; Parkinson s disease dementia; dementia;

    Abstract : Alzheimer disease (AD) is the most common type of dementia and characterized by the accumulation of amyloid plaques in the extracellular space of the brain parenchyma. Amyloid plaques consist of amyloid beta peptides (Aβ). Amyloid pathology can also be involved in other types of dementia, either as a driving force or as a coexisting pathology. READ MORE

  5. 3. L68Q cystatin C: Expression, cellular transport and turnover of the cystatin C variant forming amyloid in patients with Hereditary Cystatin C Amyloid Angiopaty (HCCAA)

    Author : María Bjarnadóttir; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cysteine proteinase inhibitor; brain haemorrhage; amyloid; cystatin C; HCCAA; Clinical chemistry; Klinisk kemi;

    Abstract : Hereditary cystatin C amyloid angiopathy (HCCAA) is a disorder characterised by multiple strokes in young adults, resulting in paralysis and dementia. The disease is caused by a mutation in the gene coding for the peptidase inhibitor cystatin C. READ MORE

  6. 4. Observations on cerebral amyloid angiopathy and microvascular pathology in Alzheimer's disease and vascular dementia

    Author : Mattias Haglund; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patologi allmän ; pathological anatomy; General pathology; Vascular dementia; Alzheimer s disease; Cerebral infarction; Locus ceruleus; White matter; Microvasculature; Cerebrovascular disease; patologisk anatomi; Ischemia; Cerebral amyloid angiopathy;

    Abstract : Dementia is a state of permanent loss of cognitive function, most commonly affecting the elderly. With a rapidly growing aged population, the spectrum of disorders that lead to dementia is exerting an ever-increasing toll on patients, families and society alike. The most common dementing disorders are Alzheimer's disease and vascular dementia. READ MORE

  7. 5. Microangiopathies of the human brain b immunohistochemical studies on extracellular matrix components in arterial vessels and endothelin

    Author : Wei Wei Zhang; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Microangiopathy; human brain; hyalinosis; amyloid angiopathy; CADASIL; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Abstract : Microangiopathies may cause ischemic brain lesions and are of fundamental importance in vascular dementia. Risk factors include high age, hypertension, diabetes and Alzheimer's disease. READ MORE