Advanced search

Showing result 1 - 5 of 52 swedish dissertations matching the above criteria.

  2. 1. Processing of the amyloid precursor protein and its paralogues amyloid precursor-like proteins 1 and 2

    Author : Linda Adlerz; Kerstin Iverfeldt; Richard Cowburn; Stockholms universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; APP; APLP1; APLP2; Alzheimer s disease; Amyloid β-peptide; Processing; RA; BDNF; IGF-1; curcumin; PI3-K; MAPK; cdk5; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disorder which is histopathologically characterised by amyloid plaques and neurofibrillary tangles. Amyloid plaques consist of the amyloid β-peptide (Aβ) that can form aggregates in the brain. Aβ is generated from the amyloid precursor protein (APP) through proteolytic cleavage. READ MORE

  4. 2. Evaluation of amyloid precursor protein and ß-amyloid as biomarkers for Alzheimer s disease

    Author : Annika Olsson; Göteborgs universitet; []
    Keywords : Alzheimer s disease; amyloid precursor protein; ß-amyloid; biomarker; cerebrospinal fluid; enzyme-linked immunosorbent assay; plasma;

    Abstract : Alzheimer s disease (AD) is a neurodegenerative disorder characterised by accumulations of neurofibrillary tangles and amyloid plaques. The major components of the amyloid deposits are the ß-amyloid (Aß) peptides derived from the amyloid precursor protein (APP). READ MORE

  5. 3. Physiological role of amyloid precursor protein during neural development

    Author : Rakesh Kumar Banote; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloid precursor protein; Zebrafish; Spinal cord; Motor neurons; Hindbrain; Mauthner cell; Development; Proteomics;

    Abstract : Amyloid precursor protein (APP) is a type-one membrane-spanning protein with a large extracellular N-terminal domain and a small intracellular C-terminal domain. APP first gained interest due to its involvement in the pathogenesis of Alzheimer’s disease (AD). READ MORE

  6. 4. Studies of amyloid precursor protein trafficking and processing

    Author : Shaohua Xu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer’s disease (AD) is the most common form of neurodegenerative disease that slowly impairs memory and thinking abilities. Abnormal accumulation and aggregation of amyloid β peptides (Aβ), derived from proteolytic cleavage of the amyloid precursor protein (APP), is thought to be one of the critical triggers in the pathogenesis. READ MORE

  7. 5. The amyloid-β precursor protein (APP) and its adaptor protein Fe65 : Two key players in Alzheimer’s disease

    Author : Preeti Menon; Anna-Lena Ström; Thorsten Müller; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; APP; Fe65; Meprinβ; α-secretase; APP processing; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the abnormal accumulation and aggregation of amyloid beta (Aβ) peptides within the brain. Generation of Aβ occur when the amyloid-beta precursor protein (APP) is proteolytically processed by β- and then γ-secretase in the amyloidogenic pathway. READ MORE