Search for dissertations about: "amyloid structure"

Showing result 16 - 20 of 102 swedish dissertations containing the words amyloid structure.

  2. 16. Accumulation and Cellular Clearance of IAPP and Proteotoxicity of ATTR in Drosophila Models

    Author : Xiaohong Gu; Gunilla Westermark; Anders Olofsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; IAPP; ATTR; ATTR amyloidosis; crystalline structure; aggrephagy; Drosophila melanogaster; Gal4-UAS; electron tomography; DAMS; SOHA; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : Proteins’ functions are dependent on their three-dimensional (3D) structure. Under certain circumstances, proteins misfold and form aggregates, sometimes leading to amyloidosis. Islet amyloid polypeptide (IAPP) builds up amyloid in the pancreatic islet of patients with type 2 diabetes (T2D). READ MORE

  4. 17. Size determination of hyaluronan and multivariate analysis of amyloid prone proteins

    Author : Linus Malm; Göran Larsson; Henrik Antti; Mary Cowman; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hyaluronan; Dynamic Light Scattering; GEMMA; Amyloid Aggregation; Multivariate Analysis; Biochemistry; Biokemi; medicinsk biokemi; Medical Biochemistry; fysikalisk kemi; Physical Chemistry;

    Abstract : Background.The extracellular matrix surrounds all cells within our bodies. The glycosaminoglycan hyaluronan is a major component in the extracellular matrix. Despite its structural simplicity it has been shown to be involved in several important functions. READ MORE

  5. 18. Co-assembly of proteins and lipids : From lipodiscs to amyloid aggregates

    Author : Rebecca Frankel Willén; NanoLund: Centre for Nanoscience; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amyloid; Aβ42; apolipoprotein A-1; aggregation; high-density lipoprotein; DNAJB6; Alzheimer s disease; protein-lipid interactions;

    Abstract : Assemblies of different molecules is a prevalent phenomenon in nature, and crucial in biological life. Most of the biological assemblies are co-assembledcomposites, made up from several different components, either of thesame biomolecular type or a combination of different ones. READ MORE

  6. 19. Amyloid β peptide: from monomer solubility to fibril structure

    Author : Veronica Lattanzi; NanoLund: Centre for Nanoscience; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Alzheimer´s disease; Aβ solubility; small angle scattering; number of filaments; Aβ40; Aβ42 and Aβ42 S26Q ; fibril structure;

    Abstract : Alzheimer´s disease (AD) is the most common human neuro-degenerative disease characterized by the formation of cerebral plaques. Several are the amyloid-beta (Aβ) variants found in the brain of healthy individuals. READ MORE

  7. 20. Capturing transient peptide assemblies associated with Alzheimer's disease : Native mass spectrometry studies of amyloid-β oligomerization

    Author : Nicklas Österlund; Astrid Gräslund; Leopold L. Ilag; Mikael Oliveberg; Sheena E. Radford; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein aggregation; amyloid-β; neurodegeneration; Alzheimer’s disease; chaperones; DnaJ; biomembranes; native mass spectrometry; Biophysics; biofysik;

    Abstract : Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and aggregation of proteins, where non-native intermolecular interactions form large and highly ordered amyloid aggregates with low free energy, is hence associated with multiple diseases. READ MORE