Search for dissertations about: "amyloid structure"
Showing result 21 - 25 of 102 swedish dissertations containing the words amyloid structure.
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21. alpha-synuclein: amyloid fibrils and interactions with lipid membranes
Abstract : The second most common neurodegenerative disease, Parkinson’s disease, is linked with an amyloid forming protein, alpha-synuclein. Hallmarks of Parkinson’s disease are progressive loss of dopaminergic neurons and accumulation of intraneuronal inclusions termed Lewy bodies. READ MORE
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22. Apolipoprotein A-IV and Transthyretin in Swedish Forms of Systemic Amyloidosis
Abstract : Over 20 different plasma proteins have been shown to have the capacity to undergo conformational changes and self-assemble into highly stable and insoluble amyloid fibrils. One, transthyretin (TTR), consists of 127 amino acid residues arranged in eight β-strands (named A to H) and is involved in two different clinical forms of amyloidosis. READ MORE
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23. Amyloid aggregates: detection and interaction
Abstract : The research on protein aggregation and amyloid formation is motivated by the fact that amyloid formation in tissue is harmful and associated with several debilitating diseases including Alzheimer’s disease (AD) and systemic amyloidosis such as transthyretin (ATTR) amyloidosis. Nevertheless, their beneficial roles in Nature have recently been identified, and artificial self-assembling of amyloid structure for various applications are emerging. READ MORE
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24. Amyloid-β and lysozyme proteotoxicity in Drosophila : Beneficial effects of lysozyme and serum amyloid P component in models of Alzheimer’s disease and lysozyme amyloidosis
Abstract : In the work presented this thesis, two different conditions that are classified as protein misfolding diseases: Alzheimer's disease and lysozyme amyloidosis and proteins that could have a beneficial effect in these diseases, have been studied using Drosophila melanogaster, commonly known as the fruit fly. The fruit fly has been used for over 100 years to study and better understand fundamental biological processes. READ MORE
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25. The choreography of protein vibrations : Improved methods of observing and simulating the infrared absorption of proteins
Abstract : The work presented in this thesis has striven toward improving the capability to study proteins using infrared (IR) spectroscopy. This includes development of new and improved experimental and theoretical methods to selectively observe and simulate protein vibrations. READ MORE