Search for dissertations about: "amyloid"

Showing result 21 - 25 of 499 swedish dissertations containing the word amyloid.

  2. 21. Evaluation of amyloid precursor protein and ß-amyloid as biomarkers for Alzheimer s disease

    Author : Annika Olsson; Göteborgs universitet; []
    Keywords : Alzheimer s disease; amyloid precursor protein; ß-amyloid; biomarker; cerebrospinal fluid; enzyme-linked immunosorbent assay; plasma;

    Abstract : Alzheimer s disease (AD) is a neurodegenerative disorder characterised by accumulations of neurofibrillary tangles and amyloid plaques. The major components of the amyloid deposits are the ß-amyloid (Aß) peptides derived from the amyloid precursor protein (APP). READ MORE

  4. 22. Roles of Heparan Sulfate in Amyloid-β Pathology and Hypoxia

    Author : Elina Hjertström; Jin-ping Li; Ulf Lindahl; Sally Stringer; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heparan sulfate; Alzheimer s disease; Aβ; Proteoglycan; Heparanase; Amyloid; Hypoxia; Cancer; Spalax; Biochemistry; Biokemi; Medical Biochemistry; Medicinsk biokemi;

    Abstract : Heparan sulfate (HS) is a highly sulfated polysaccharide expressed on the cell surface and in the extracellular matrix, interacting with a large number of proteins. HS is implicated in human diseases, including different types of cancer and amyloid diseases such as Alzheimer's disease (AD). READ MORE

  5. 23. Cellular Uptake of Amyloid Forming Proteins Related to Neurodegenerative Disease

    Author : Emelie Vilhelmsson Wesén; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aβ 1-40 ; flow cytometry; confocal microscopy; SH-SY5Y; fluorescence; Aβ 1-42 ; Alzheimer’s disease; amyloid fibril; α-synuclein; amyloid-β;

    Abstract : Aggregation and deposition of disease-associated protein is a pathological hallmark of several human disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). These diseases are characterized by the formation of amyloid-β (Aβ) and α-synuclein (α-syn) amyloid fibrils, in extracellular and intracellular locations, respectively. READ MORE

  6. 24. Electrophoretic focusing in microchannels combined with mass spectrometry : Applications on amyloid beta peptides

    Author : Saara Mikkonen; Åsa Emmer; Johan Jacksén; Tapio Kotiaho; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; amyloid beta; computer simulation; electrophoresis; electrospray ionization; isoelectric focusing; isotachophoresis; MALDI; mass spectrometry; microchannel; microchip; nano-electrospray ionization; preconcentration; separation; Kemi; Chemistry;

    Abstract : Analysis of low-abundance components in small samples remains a challenge within bioanalytical chemistry, and new techniques for sample pretreatments followed by sensitive and informative detection are required. In this thesis, procedures for preconcentration and separation of proteins and peptides in open microchannels fabricated on silicon microchips are presented. READ MORE

  7. 25. The Impact of Amyloid Peptides on Pericytes in Alzheimer's Disease

    Author : Nina Schultz; Klinisk minnesforskning; []
    Keywords : Pericytes; Alzheimer s disease; Amyloid peptides; IAPP; Amyloid beta 1-42; Amyloid beta 1-40; Cell death; NG2; Retina; Hippocampus;

    Abstract : .... READ MORE