Search for dissertations about: "amyotrophic lateral sclerosis"

Showing result 16 - 20 of 86 swedish dissertations containing the words amyotrophic lateral sclerosis.

  2. 16. Mutant superoxide dismutase-1-caused pathogenesis in amyotrophic lateral sclerosis

    Author : Daniel Bergemalm; Stefan Marklund; Thomas Brännström; Peter Andersen; Caterina Bendotti; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD1; mitochondria; proteome; transgenic mice; inclusion; Clinical chemistry; Klinisk kemi; biokemi; Biochemistry; neurologi; Neurology; Clinical Chemistry; klinisk kemi; patologi; Pathology;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a devastating disease that affects people in their late mid-life, with fatal outcome usually within a few years. The progressive degeneration of neurons responsible for muscle movement (motor neurons) throughout the central nervous system (CNS) leads to muscle wasting and paralysis, and eventually affects respiratory function. READ MORE

  4. 17. T cell responses in amyotrophic lateral sclerosis : friends or foes?

    Author : Solmaz Yazdani; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Amyotrophic lateral sclerosis (ALS) is an idiopathic fatal neurodegenerative disease that is characterized by the loss of upper and lower motor neurons. Inflammation is widely recognized as a hallmark of this disease; however, the intricate relationship between immune biomarkers and the pathogenesis of ALS is not fully understood yet. READ MORE

  5. 18. Immunity and inflammation in amyotrophic lateral sclerosis : an epidemiological approach

    Author : Can Cui; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a rare but lethal neurodegenerative disease, characterized by degeneration of both upper and lower motor neurons in the brain and spinal cord. The pathogenesis of ALS is, however, not completely clear. READ MORE

  6. 19. Misfolded superoxide dismutase-1 in sporadic and familial Amyotrophic Lateral Sclerosis

    Author : Karin Forsberg; Thomas Brännström; Irina Alafuzoff; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; SOD-1 motor neuron; protein misfolding; intranuclear; antibodies; CNS; brain; patologi; Pathology;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative syndrome of unknown etiology that most commonly affects people in middle and high age. The hallmark of ALS is a progressive and simultaneous loss of upper and lower motor neurons in the central nervous system that leads to a progressive muscle atrophy, paralysis and death usually by respiratory failure. READ MORE

  7. 20. Biomedical factors in the risk and prognosis of amyotrophic lateral sclerosis

    Author : Jiangwei Sun; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Amyotrophic lateral sclerosis (ALS) is a relatively rare but incurable and relentlessly progressive neurodegenerative disease, characterized by motor neuron loss in the brain and spinal cord. Majority of patients die within 3-5 years after symptom onset, commonly due to respiratory failure. READ MORE