Search for dissertations about: "analgesic"

Showing result 1 - 5 of 119 swedish dissertations containing the word analgesic.

  2. 1. Patient-controlled analgesic therapy : the pharmacokinetics of three opiate analgesics in surgical patients and the relation between postoperative demand for analgesics and individual levels of endorphins and substance P in cerebrospinal fluid

    Author : Anders Tamsen; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  4. 2. The analgesic mechanisms of buprenorphine

    Author : Poli Francois Kouya; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Buprenorphine; morphine; cross-tolerance; g- opioid receptors; inbred mice.;

    Abstract : Buprenorphine, a derivative of thebaine, is a semi-synthetic opiate and a partial p-opioid receptor agonist. Buprenorphine is also a weak kappa-opioid receptor antagonist. Buprenorphine is used clinically as an analgesic and for maintenance therapy of opiate-dependent subjects because it produces limited withdrawal symptoms. READ MORE

  5. 3. Sinomenine as a novel analgesic : mechanisms and applications

    Author : Tiansheng Shi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic pain of various origins is a major health care issue affecting a large patient population, also bring significant social and economic cost on the society. Work presented in this thesis concerns novel methods of treatments for chronic pain using experimental models. READ MORE

  6. 4. Human experimental pain models : methodological and analgesic studies

    Author : Helène Schulte; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Pain; human volunteers; pain threshold; hyperalgesia; opioids; ketamine;

    Abstract : Pain is an important clinical issue with great impact on society and individuals' well being. It is well established that sensory abnormalities induced by tissue trauma and inflammation are clinically important in various acute and chronic pain conditions. READ MORE

  7. 5. Olfactory Transfer of Analgesic Drugs After Nasal Administration

    Author : Ulrika Espefält Westin; Erik Björk; Eva Brittebo; Margareta Hammarlund-Udenaes; Paolo Colombo; Uppsala universitet; []
    Keywords : Pharmaceutics; Nasal administration; Olfactory transfer; Olfactory pathways; Central nervous system; Blood-brain barrier; Nasal respiratory mucosa; Olfactory mucosa; Olfactory bulb; Horizontal Ussing chamber; Morphine; Dihydroergotamine; Rat; Mouse; Swine; Autoradiography; Viability; Powder formulations; Galenisk farmaci;

    Abstract : Nasal administration of analgesics for achieving rapid pain relief is currently a topic of great interest. The blood-brain barrier (BBB) restricts access to the central nervous system (CNS) for several central-acting drugs, such as morphine and dihydroergotamine, which results in a substantial effect delay. READ MORE