Search for dissertations about: "analytical method validation"

Showing result 1 - 5 of 47 swedish dissertations containing the words analytical method validation.

  1. 1. Development of Field-adapted Analytical Methods for the Determination of New Antimalarial Drugs in Biological Fluids

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Niklas Lindegårdh; Uppsala universitet.; Högskolan Dalarna.; [2003]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES Chemistry Analytical chemistry; NATURVETENSKAP Kemi Analytisk kemi; Analytical Chemistry; analytisk kemi; Analytical chemistry; LC; liquid chromatography; biological samples; SPE; solid phase extraction; validation; antimalarial drugs; amodiaquine; piperaquine; atovaquone; dried blood spots; Analytisk kemi;

    Abstract : This thesis deals with the development of analytical methods for the determination of new antimalarial drugs in biological fluids. The goal was to develop methods that facilitate clinical studies performed in the field, such as capillary blood sampling onto sampling paper. READ MORE

  2. 2. Drug Analysis Bioanalytical Method Development and Validation

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mikaela Malm; Uppsala universitet.; [2008]
    Keywords : Analytical chemistry; African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine; Analytisk kemi;

    Abstract : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries.Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. READ MORE

  3. 3. Development and Validation of HPLC Methods for Analytical and Preparative Purposes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Johan Lindholm; Uppsala universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; High performance liquid chromatography HPLC ; Analytical biotechnology; Sample preparation; Diode-array-detection DAD ; Mass spectrometry MS ; Validation; Preparative chromatography; Competitive isotherm parameters; Perturbation peak PP method; Kemi; NATURAL SCIENCES Chemistry; NATURVETENSKAP Kemi;

    Abstract : This thesis concerns the development and validation of high performance liquid chromatography (HPLC) methods aimed for two industrially important areas: (i) analysis of biotechnological synthesis and (ii) determination of adsorption isotherm parameters. There is today a lack of detailed recommendations for analytical procedures in the field of biotechnological production of drugs. READ MORE

  4. 4. Mass Spectrometry and Affinity Based Methods for Analysis of Proteins and Proteomes

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Mårten Sundberg; Uppsala universitet.; [2015]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; proteomics; microarray; protein; antibody; antigen; affinity; validation; Kemi med inriktning mot analytisk kemi; Chemistry with specialization in Analytical Chemistry;

    Abstract : Proteomics is a fast growing field and there has been a tremendous increase of knowledge the last two decades. Mass spectrometry is the most used method for analysis of complex protein samples. It can be used both in large scale discovery studies as well as in targeted quantitative studies. READ MORE

  5. 5. Adsorption Isotherm Parameter Estimation in Nonlinear Liquid Chromatography

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Patrik Forssén; Uppsala universitet.; Uppsala universitet.; [2005]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; High performance liquid chromatography HPLC ; Preparative chromatography; Competitive adsorption isotherm parameters; Perturbation peak PP method; Inverse method IM ; Computer simulation; Parameter estimation; Numerical method; Scientific Computing; Beräkningsvetenskap;

    Abstract : This thesis concerns the development and validation of methods for the industrially important area of adsorption isotherm parameter estimation in preparative, nonlinear high performance liquid chromatography (HPLC). Preparative chromatography is a powerful separation method to get pure compounds from more or less complex liquid mixtures, e.g. READ MORE