Search for dissertations about: "ancestral"

Showing result 1 - 5 of 128 swedish dissertations containing the word ancestral.

  1. 1. Engineering enzymes towards biotherapeutic applications using ancestral sequence reconstruction

    Author : Natalie Hendrikse; Per-Olof Syrén; Johan Rockberg; Erik Nordling; Reinhard Sterner; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; enzyme engineering; enzyme evolution; ancestral sequence reconstruction; therapeutic enzymes; terpene cyclases; ammonia-lyases; sulfatases; lysosomal enzymes; Kemi; Chemistry;

    Abstract : Enzymes are versatile biocatalysts that fulfill essential functions in all forms of life and, therefore, play an important role in health and disease. One specific application of enzymes in life science is their use as biopharmaceuticals, which typically benefits from high catalytic activity and stability. READ MORE

  2. 2. Ancestral influences on health of grandchildren

    Author : Gunnar Kaati; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The late effects in adulthood of nutrition during adolescence, childhood, infancy, and the fetal and embryonic stages of development have attracted much attention in research, but less so the time of development of the genome. The issue of fetal origins of adult disease has particularly attracted interest. READ MORE

  3. 3. Spatial Statistics and Ancestral Recombination Graphs with Applications in Gene Mapping and Geostatistics

    Author : Linda Werner Hartman; Matematisk statistik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genetik; Genetics; cytogenetics; cytogenetik; genetic association analysis; ancestral recombination graph Generalized linear mixed models; kriging; bilinear interpolation; Gaussian Markov random fields; Statistics;

    Abstract : This thesis explores models and algorithms in geostatistics and gene mapping. The first part deals with the use of computationally effective lattice models for inference of data with a continuous spatial index. READ MORE

  4. 4. The Dawn of a New Age : Interrelationships of Acoela and Nemertodermatida and the Early Evolution of Bilateria

    Author : Andreas Wallberg; Ulf Jondelius; Mikael Thollesson; Graham Budd; Gonzalo Giribet; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Acoela; Nemertodermatida; Bilateria; Metazoa; evolution; phylogenetic inferrence; ancestral reconstruction; taxon sampling; microRNA; Systematics and phylogenetics; Systematik och fylogeni; systematisk zoologi; Systematic Zoology;

    Abstract : Deciphering the rapid emergence of bilaterian animals around the time of the Cambrian Explosion and reconstructing the interrelationships of animal groups have long been two of the most elusive problems in Zoology. This thesis concerns the phylogenetic interrelationships within and among Acoela and Nemertodermatida, two groups of small worms that are believed to be basal bilaterians and which may provide important clues for understanding the early evolution of animals. READ MORE

  5. 5. Drosophila Sensory Neuroethology

    Author : Suzan Mansourian; Funktionell zoologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; Vinegar Fly; olfactory system; hygrosensation; receptor; ancestral habitat;

    Abstract : Animals, like humans, need to perceive their surroundings via their senses in order to make sensible behavioral decisions, reproduce successfully, and survive. Animals are equipped with audition, vision, thermosensation, hygrosensation, mechanosensation, magnetoception, gustation, and olfaction, which detects physical and chemical changes in their habitats. READ MORE