Search for dissertations about: "ancestry markers"

Showing result 1 - 5 of 7 swedish dissertations containing the words ancestry markers.

  2. 1. Complex disease genetics : Utilising targeted sequencing and homogeneous ancestry

    Author : Argyri Mathioudaki; Kerstin Lindblad-Toh; Panagiotis Deloukas; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ankylosing spondylitis; breast cancer; targeted sequencing; Sweden; genetics; population stratification.; Molekylär genetik; Molecular Genetics;

    Abstract : The complex disease investigations presented in this thesis aimed to provide new information regarding underlying genetics by using targeted sequencing and ethnically homogeneous cohorts. This work moved past current methodologies and addressed data stratification issues, that might have been hindering new findings. READ MORE

  4. 2. Welander distal myopathy : gene mapping and analysis of candidate genes

    Author : Désirée von Tell; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Welander Distal Myopathy; 2p13; linkage; candidate genes; founder mutation; mutation screening.;

    Abstract : Distal myopathies constitute of a very heterogeneous group of muscular disorders. Distal myopathies have previously been classified according to features such as; clinical symptoms, age of onset and histopathological changes. READ MORE

  5. 3. Investigation of genetic factors in multiple sclerosis

    Author : Izaura Lima Bomfim; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is a chronic disease where the transmission of signals in the central nervous system is affected leading to a broad range of symptoms. The aetiology of the disease is unknown but multiple genetic and environmental factors are believed to play a part. READ MORE

  6. 4. Environmental regulation of metabolism : from transgenerational effects of nutrition to acute effects of exercise

    Author : Petter Alm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The incidence of metabolic disease has risen rapidly in the last half-century leading to both individual suffering and a burden to society. The importance of physical activity for metabolic health is well known. Furthermore, there is increasing evidence that parental food choice and obesity can affect the metabolic health of future generations. READ MORE

  7. 5. Statistical Modeling and Learning of the Environmental and Genetic Drivers of Variation in Human Immunity

    Author : Jacob Bergstedt; Institutionen för reglerteknik; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Abstract : During the last decade the variation in the human genome has been mapped in fine detail. Next generation sequencing has made it possible to cheaply and rapidly aquire vast amounts of biomolecular information on large cohorts of people. READ MORE