Search for dissertations about: "androgen receptor"
Showing result 21 - 25 of 111 swedish dissertations containing the words androgen receptor.
-
21. Roles of Androgens in Cardiovascular Physiology and Pathophysiology
Abstract : ABSTRACT Atherosclerosis is the major underlying cause of cardiovascular disease, such as myocardial infarction (MI) and stroke, and these conditions are the leading causes of death both in Sweden and globally. The immune system is involved in the pathogenesis of atherosclerosis as well as post-MI cardiac injury. READ MORE
-
22. Cellular mechanisms of taxane therapy in castration resistant prostate cancer
Abstract : Chemotherapy of castration resistant prostate cancer (CRPC) is based on taxane formulations worldwide. Only 30-50 % of patients respond to this therapy and the exact cellular mechanisms of taxane resistance in PC cells are not fully elucidated. There is convincing evidence that androgen receptor (AR) is affected by exposure to these compounds. READ MORE
-
23. Molecular heterogeneity of prostate cancer bone metastasis
Abstract : Castration-resistant prostate cancer (CRPC) develops after androgen deprivation therapy of advanced PC, often with metastatic growth in bone. Patients with metastatic CRPC have very poor prognosis. Growth of CRPC, in most but not all patients, seems to involve androgen receptor (AR) activity, despite castrate levels of serum testosterone. READ MORE
-
24. Translational and functional analyses of microRNAs in prostate cancer
Abstract : The aims of this thesis were to identify microRNAs (miRNAs) with prostate cancer prognostic and diagnostic potential, to discover miRNAs with therapeutic capacity against prostate cancer, and to investigate if prostate specific antigen (PSA) is miRNA regulated. Prostate cancer is a globally spread disease with low mortality, but some patients develop an aggressive lethal form of prostate cancer with severe morbidity. READ MORE
-
25. Evaluation of regulator of G-protein signaling 2 (RGS2) at different stages of prostate cancer - Significance and clinical potential
Abstract : Prostate cancer (PC) is often a slow-growing and symptom-free disease with good prognosis. However, a substantial number will progress, ultimately metastasize if left untreated and finally kill the patient. The standard treatment for these stages of PC is androgen deprivation therapy (ADT), which generally has an initially good clinical response. READ MORE