Search for dissertations about: "angiopoietin-like protein 4"

Found 5 swedish dissertations containing the words angiopoietin-like protein 4.

  2. 1. Angiopoietin-like protein 4 : an unfolding chaperone regulating lipoprotein lipase activity

    Author : Valentina Sukonina; Gunilla Olivecrona; Lena Kjellen; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; angiopoietin-like protein 4; protein folding; human adipose tissue; macrophages; peroxisome proliferator-activated receptor delta PPARδ ; Medical microbiology; Medicinsk mikrobiologi;

    Abstract : Lipoprotein lipase (LPL) is the main enzyme hydrolyzing triglyceride-rich lipoproteins in plasma. Proteoglycan-bound LPL on the vascular endothelium represent the functional pool of active enzyme. LPL is regulated in a tissue specific manner according to metabolic demands. READ MORE

  4. 2. Mechanoregulation of angiopoietin-like 4 in epithelial-mesenchymal transition and cancer metastasis

    Author : Zehuan Liao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The epithelial-mesenchymal transition (EMT) serves as a pivotal mechanism in the progression of metastatic cancer. However, current research, predominantly reliant on 2D monolayer cultures, inadequately replicates the intricate nature of a 3D tumor microenvironment. READ MORE

  5. 3. Localization of lipoprotein lipase in mouse pancreas, kidney and placenta : impact of metabolic disturbances on cellular distribution and activity regulation

    Author : Rakel Nyrén; Gunilla Olivecrona; Paolo Parini; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipoprotein lipase; pancreas; kidney; placenta; angiopoietin-like protein 4; high-fat diet; obesity; mice; PET CT; nutritional status; triglyceride; GPIHBP1; medicinsk och fysiologisk kemi; Medical and Physiological Chemistry;

    Abstract : Lipoprotein lipase (LPL) is the key enzyme for metabolism of triglycerides in plasma lipoproteins. In recent years many new facts about the enzyme and its regulation have been uncovered. The endothelial membrane protein GPIHBP1 translocates LPL through endothelial cells and holds the enzyme in place at the luminal side of the capillary endothelium. READ MORE

  6. 4. Novel factors affecting clearance of triacylglycerol-rich lipoproteins from blood

    Author : Stefan K Nilsson; Gunilla Olivecrona; Aivar Lookene; Ko Willems van Dijk; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipoprotein; triacylglycerol; apolipoprotein A-V; ANGPTL; Cardiovascular medicine; Kardiovaskulär medicin; medicinsk biokemi; Medical Biochemistry;

    Abstract : Apolipoprotein (apo) A-V is the most recently discovered member of a protein family responsible for the structure and metabolic fate of plasma lipoproteins. While most of the apolipoproteins are well characterized with regard to structure, interactions and function, the role of apoA-V is not well understood. READ MORE

  7. 5. Endogenous and exogenous factors affecting lipoprotein lipase activity

    Author : Mikael Larsson; Gunilla Olivecrona; Aivar Lookene; Ira Tabas; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LPL; APOC1; APOC2; APOC3; ANGPTL4; enzyme inactivation; lipoprotein metabolism; triglycerides; fatty acids; hypertriglyceridemia; CVD; small molecule screening; structure-activity relationship; cardiovascular disease; hjärt- och kärlforskning;

    Abstract : Individuals with high levels of plasma triglycerides are at high risk to develop cardiovascular disease (CVD), currently one of the major causes of death worldwide. Recent epidemiological studies show that loss-of-function mutations in the APOC3 gene lower plasma triglyceride levels and reduce the incidence of coronary artery disease. READ MORE