Search for dissertations about: "animal expression transfer"

Showing result 1 - 5 of 25 swedish dissertations containing the words animal expression transfer.

  2. 1. Development of Gene Therapy for Hematopoietic Stem Cells using Lentiviral Vectors

    Author : Niels-Bjarne Woods; Andreas Ooka; Stefan Karlsson; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; embryonic stem cell; Hematopoietic stem cell; lentiviral vector; transduction efficiency; transgene expression; multiple vector copy integration; insertional mutagenesis; NOD SCID mouse; cytogenetics; Genetics; extracellulära vätskor; extracellular fluids; cytogenetik; Genetik; Haematology; Hematologi; Lentivirus : genetics; Human; Genetic Vectors; Hematopoietic Stem Cells : metabolism; Animal; Gene Therapy; Leukemia : therapy; Leukemia : metabolism;

    Abstract : Hematopoietic stem cells are an ideal target for genetic manipulation for the purpose of curing hematological disorders as they have the ability to develop into all blood lineages and to self-renew. In this study we demonstrate that lentiviral vectors, based on HIV-1, can efficiently transfer genes into human hematopoietic progenitor and stem cells as assessed following stem cell transplantation in immune compromised mice. READ MORE

  4. 2. Facets of Fun: On the Design of Computer Augmented Entertainment Artifacts

    Author : Sus Lundgren; Chalmers tekniska högskola; []
    Keywords : HUMANIORA; HUMANITIES; NATURVETENSKAP; NATURAL SCIENCES; game mechanics; animal expression transfer; Game Design Patterns; the Iron Horse; design tools; remnants; slow technology; the Forces-Clashes-Remnants model; clashes; myTHeme; Interactive entertainment artifacts; forces; the Interactive Quilt; MultiMonsterMania; The Hatchery;

    Abstract : This thesis discusses the design of interactive entertaining artifacts such as computer games and computer augmented toys, games and objects. The aim has been to find and/or develop design tools i.e. READ MORE

  5. 3. Experimental Stroke and Neurotrophins: Regulation, function and gene transfer of neurotrophins in rat and mouse models of focal cerebral ischemia

    Author : Gunnar Andsberg; Lund Neurologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsychology; Neurology; animal behaviour; striatum; stereology; immunohistochemistry; focal cerebral ischemia; nerve growth factors; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : Stroke caused by focal cerebral ischemia is a major cause of death and neurological disability in humans. The forebrain region most commonly affected by ischemic incidents is that supplied by the middle cerebral artery. READ MORE

  6. 4. Modeling pathophysiological aspects of Parkinson’s disease: Manipulating DA handling and alpha-synuclein expression in the nigrostriatal pathway using viral vectors

    Author : Ayse Ulusoy; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease; adeno-associated virus; dopamine; α-synuclein; tyrosine hydroxylase; RNAinterference; shRNA; substantia nigra; animal models; dyskinesia;

    Abstract : The pathological hallmark of Parkinson’s disease is dopaminergic neurodegeneration in the substantia nigra pars compacta neurons and accumulation of α-synuclein containing aggregates in the surviving neurons. The cause of cell death in Parkinson’s disease and the involvement of α-synuclein in the pathophysiology of the disease are unknown. READ MORE

  7. 5. Evolutionary consequences of maternal effects and stress

    Author : Piotr K. Rowiński; Björn Rogell; Karl Gotthard; Katja Räsänen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; parental effects; meta-analysis; development time; bet-hedging; brain size; evolutionary potential; unpredictable environments; zoologisk ekologi; Animal Ecology;

    Abstract : Maternal effects occur when maternal environment or phenotype influence offspring phenotype, in addition to genetic contribution of the mother. As maternal effects often influence phenotypes that are under natural selection, they hence have evolutionary consequences. READ MORE