Search for dissertations about: "ankyrin repeat domain"

Showing result 1 - 5 of 8 swedish dissertations containing the words ankyrin repeat domain.

  2. 1. Thermo- and chemosensitive properties of Transient Receptor Potential Ankyrin 1 ion channels

    Author : Lavanya Moparthi; Biokemi och Strukturbiologi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; TRP ion channels; TRPA1; ankyrin repeat domain; thermosensation; chemosensation; cold sensor; electrophiles; non-electrophiles; planar lipid bilayers; patch-clamp; fluorescence spectroscopy; mass spectrometry;

    Abstract : The ability to sense and accommodate to an ever-changing environment is crucial for the survival of living organisms. Transient Receptor Potential (TRP) ion channels comprise a large superfamily of cation conducting membrane proteins that function as molecular sensors in diverse sensory processes including perception of light, taste, smell, sound, touch and temperature. READ MORE

  4. 2. Characterization of ankyrin repeat domain 54 (ANKRD54) and its role on the regulation and subcellular localization of Bruton’s tyrosine kinase (BTK)

    Author : Manuela O Gustafsson Sfetcovici; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Bruton's tyrosine kinase (BTK) is an important cytoplasmic signaling protein, where the kinase activity plays a pivotal role in the development, proliferation and differentiation of B-cell lineages. Ankyrin repeat domain 54 (ANKRD54) is a nuclear-resident adaptor protein, where the ankyrin domain repeats are critical for specific protein-protein interaction, while the NLS and NES motifs control the nucleo-cytoplasmic shuttling ability. READ MORE

  5. 3. Proximity Ligation Assay for High Performance Protein Analysis in Medicine

    Author : Gucci Jijuan Gu; Ulf Landegren; Thomas Joos; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein; post-translational modification; interactions; protein domain; western blotting; MARK; tau; AD; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Abstract : High quality reagents are preconditions for high performance protein analyses. But despite progress in some techniques, e.g. mass spectrometry, there is still a lack of affinity-based detection techniques with enhanced precision, specificity, and sensitivity. READ MORE

  6. 4. Relish and the Regulation of Antimicrobial Peptides in Drosophila melanogaster

    Author : Marika Hedengren Olcott; Barbara Taylor; Jean-Marc Reichhart; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Drosophila immunity; NF-kappaB; Relish; antimicrobial peptides; Developmental biology; Utvecklingsbiologi;

    Abstract : The fruit fly Drosophila melanogaster has been a powerful model system in which to study the immune response. When microorganisms breach the mechanical barrier of the insect, phagocytosing cells and a battery of induced antimicrobial molecules rapidly attack them. These antimicrobial peptides can reach micromolar concentrations within a few hours. READ MORE

  7. 5. Role of AKT/ PKB and 14-3-3 in the regulation of B cell receptor signaling and signalosome assembly

    Author : Dara Mohammad; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : AKT/PKB is an oncogenic serine/threonine kinase regulated via the PI3K pathways. 14-3-3s represent a large group of adaptor proteins that are known to interact with a plethora of signaling proteins and regulate diverse signal transduction pathways. READ MORE