Search for dissertations about: "anti-TNF therapy"

Showing result 1 - 5 of 21 swedish dissertations containing the words anti-TNF therapy.

  1. 1. Anti-TNF therapy in rheumatoid arthritis. Effects on and predictors of work disability

    Author : Tor O Olofsson; Reumatologi och molekylär skelettbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Objectives: To study: (I) work-loss seen as sick leave and disability pension before and after the start of first anti-TNF therapy in Swedish regional and national RA cohorts; (II) baseline predictors of a good future work prognosis at diagnosis and after anti-TNF start with a special focus on the impact of the disease activity level and the disease duration at treatment start. Methods: RA patients were identified in the regional biologics register in Southern Sweden, SSATG, the national register over RA patients, SRQ, and the national biologics register, ARTIS, and linkage was performed to the Social Insurance Agency Register for day-level data on sick leave and disability pension. READ MORE

  2. 2. Biologics in Staphylococcus aureus arthritis

    Author : Abukar Ali; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Staphylococcus aureus; CTLA4-Ig; IL-1 Ra; anti-TNF therapy; mouse; septic arthritis;

    Abstract : The emergence of new type of drugs known as biologics has led to rapid disease improvements in many autoimmune arthritic patients. Nevertheless, most of these biologics are immunomodulators that may consequently increase the susceptibility of patients towards infections, such as septic arthritis. READ MORE

  3. 3. Anti-TNF therapy and malignancy in patients with rheumatoid arthritis : studies on cancer incidence, recurrence and survival

    Author : Pauline Raaschou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Tumor necrosis factor i nhibitors (TNFi) h ave become a backbone treatment of rheumatoid arthritis (RA). TNF has multiple and incompletely understood functions in tumor biology, and cancer is considered a potential adverse event of TNFi treatment. READ MORE

  4. 4. Anti-TNF treatment of chronic arthritis in clinical practice. New assessment method and predictors of efficacy and tolerability

    Author : Lars Erik Kristensen; Reumatologi och molekylär skelettbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; response; drug survival; psoriatic arthritis; Arthritis; rheumatoid arthritis; adverse events; TNF antagonists;

    Abstract : Abstract Treatment of chronic inflammatory arthritis has undergone major changes over the past years following introduction of targeted biological therapies. Tumour necrosis factor (TNF) blocking therapy has been the most important biological treatment of chronic arthritis to date. READ MORE

  5. 5. Cytokines in rheumatoid arthritis

    Author : Ann-Kristin Ulfgren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Rheumatoid arthritis; Synovitis; Immunohistochemistry; Digital image analysis; Cytokine Therapy; TNF neutralisation; Arthroscopy;

    Abstract : Rheumatoid arthritis (RA) is a chronic systemic disease characterised by inflammation in several joints. Cytokines appear to be important as both disease promoting and disease- suppressing mediators in the disease. READ MORE