Search for dissertations about: "anti-TNF therapy"
Showing result 11 - 15 of 21 swedish dissertations containing the words anti-TNF therapy.
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11. Predicting and monitoring disease course in rheumatoid arthritis : imaging, biomarkers, risk factors, and integrative medicine
Abstract : Rheumatoid arthritis (RA), the most common inflammatory arthritis, is a chronic, potentially debilitating autoimmune disease that can lead to functional disability, bone erosion, and chronic pain. The modern era of treatment has led to major advancements in treating this condition, especially if patients are treated early within a ‘window of opportunity’ with potent disease-modifying antirheumatic drugs (DMARDs) and a ‘treat-to-target’ approach aiming towards low disease activity or remission. READ MORE
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12. New treatment strategies for growth failure caused by chronic inflammation in children
Abstract : Chronic inflammation during childhood often leads to impaired bone growth and reduced height in adulthood. Interleukin-1β (IL-1β), interleukin-6 (IL-6) and the tumour necrosis factor-α (TNF-α) are pro-inflammatory cytokines up-regulated during chronic inflammation. READ MORE
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13. Danger within : HMGB1 as a mediator of arthritis
Abstract : Chronic arthritis occurs in childhood as juvenile idiopathic arthritis and in adults most commonly as rheumatoid arthritis. The clinical expression of these diseases differ and it is presently unknown to what extent they share pathogenic mechanisms. Optimal modes of therapy in adults generally coincide with those in children. READ MORE
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14. Disease activity, function and costs in early rheumatoid arthritis
Abstract : Rheumatoid arthritis (RA) is a major cause of progressive joint damage and disability, and is associated with decline in quality of life, reduced ability to work and increased health care utilisation. The economic consequences of the disease are substantial for the individuals and their families and for the society as a whole. READ MORE
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15. Inflammation and cytokine production in experimental neuroinflammatory disorders
Abstract : Glutamate excitotoxicity is involved in the pathogenesis of a variety of neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Kainic acid (KA), an analogue of excitotoxic glutamate, can elicit selective neuronal death in the brain of rodents, of which the pathological changes partially mimic the neurodegenerative disorders in humans. READ MORE