Search for dissertations about: "anti-TNF therapy"

Showing result 6 - 10 of 21 swedish dissertations containing the words anti-TNF therapy.

  2. 6. Studies of molecular mechanisms of action of TNF antagonists in rheumatoid arthritis

    Author : Anca Irinel Catrina; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Rheumatoid arthritis; TNF antagonists; cytokines; macrophages; matrix metalloproteinases; osteoprotegerin; RANKL; apoptosis;

    Abstract : Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by progressive bone destruction that leads to joint deformity and physical disability. Even though several therapeutic drugs are available, none have emerged as an ideal RA treatment that delays joint destruction and halts disease progression. READ MORE

  4. 7. Body composition and bone mineral density in rheumatoid arthritis : influence of inflammation and treatment with glucocorticoids and TNF-blocking agents

    Author : Inga-Lill Engvall; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory disease. Besides symptoms from the joints, changes in body composition and reduced bone mineral are common. Increased fat mass (FM) and loss of muscle mass contribute to increased morbidity and mortality. READ MORE

  5. 8. Immunological mechanisms in systemic autoimmunity : autoantibodies and chemokines in systemic lupus erythematosus and during treatment with TNF inhibitors in rheumatoid arthritis

    Author : Catharina Eriksson; Karl-Gösta Sundqvist; Solbritt Rantapää-Dahlqvist; Mari Norgren; Thomas Skogh; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoimmunity; chemokines; T-cells; autoantibodies; CD91; Clinical immunology; Klinisk immunologi; Rheumatology; Reumatologi; Clinical Immunology; klinisk immunologi; reumatologi; rheumatology;

    Abstract : Background. Rheumatoid Arthritis (RA) is an autoimmune inflammatory disease that, without powerful treatment, may lead to irreversible joint damage. During the past decade, anti-cytokine therapy has become available, e.g. READ MORE

  6. 9. Measure for measure. Outcome assessment of arthritis treatment in clinical practice

    Author : Anders Gülfe; Reumatologi och molekylär skelettbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TNF blockade; rheumatoid arthritis; utility; treatment continuation; agreement; health related quality of life; Outcome; response; psoriatic arthritis; spondyloarthritis; disease activity; observational study;

    Abstract : Objective: To investigate (i) the performance and agreement between various activity indices and response criteria in TNF-blockade of RA; (ii) the predictive ability of different response criteria and disease activity states regarding continuation of anti-TNF treatment of RA; (iii) Euro-QoL-5-dimensions utility development during TNF blockade of RA, PsA and SpA. Also, (iv) to develop a simple, utility-based outcome measure, the number needed to treat per quality adjusted life year gained (NNQ) and apply it in RA, PsA and SpA patients on anti-TNF treatment. READ MORE

  7. 10. Immune regulation and modulation of allergy and inflammatory diseases

    Author : Jeanette Grundström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inflammation is evoked in defence against invading pathogens entering the body. Sometimes inflammation is started against harmless antigens, which leads to allergic diseases, or against self-antigens or commensal microbiota as in inflammatory bowel disease (IBD). READ MORE