Search for dissertations about: "anti-cancer activity"

Showing result 1 - 5 of 82 swedish dissertations containing the words anti-cancer activity.

  2. 1. Elucidation of the molecular mechanisms of action of anti-cancer compounds reveals possible combination strategies for anti-cancer therapy

    Author : Xiaolei Zhou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer develops due to accumulation of mutations or epigenetic changes within normal cells, usually over a considerable period of time. When cancer patients are diagnosed at late stage, the tumor cells are often more heterogenous and aggressive, which results in tumor resistance to anti-cancer therapies and therefore can be lethal. READ MORE

  4. 2. Theoretical Studies of Anti-cancer Drug Tamoxifen and Estrogen Receptor Alpha

    Author : Gao Li; Yaoquan Tu; Lennart Nilsson; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : For decades tamoxifen (TAM) has been widely used for treatment of breast cancer by mediating mainly the estrogen receptor α (ERα) signaling pathways, whereby it suppresses estrogen stimulated cancer cell growth. The clinical response of TAM has been linked to cytochrome P450 2D6 (CYP2D6), which is the main isoform responsible for the conversion of TAM to the active metabolites 4-hydroxyTAM (OHT) and endoxifen. READ MORE

  5. 3. Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines

    Author : Dhana E Larsson; Dan Granberg; Sadia Hassan; Kjell Öberg; Jens F Rehfeld; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer drugs; Screening; Hollow Fiber model; Apoptosis; Oncology; Onkologi;

    Abstract : Cancer is a disease with poor response rates on available treatments. Problems with resistance and intolerance against cancer drugs are major reasons for failure of the drugs. The need to discover new cancer drugs is important. In this thesis screening of new cancer drugs and evaluation of their mechanism of action are discussed. READ MORE

  6. 4. Cloning and characterization of human deoxyribonucleoside kinases : phosphorylation of anti-cancer and anti-viral nucleoside analogs

    Author : Magnus Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : deoxyribonucleoside kinase; nucleoside analog; deoxycytidinekinase; deoxyguanosine kinase; thymidine kinase 1; thymidine kinase 2; deoxyribonucleosidephosphorylation; deoxyribonucleotides; anticancer therapy; antiviral therapy;

    Abstract : Deoxyribonucleoside kinases catalyze the phosphorylation of deoxyribonucleosides to deoxyribonucleoside monophosphates. There are four major deoxyribonucleoside kinasesin human cells: thymidine kinase 1 (TKl), deoxycytidine kinase (dCK), deoxyguanosinekinase (dGK), and thymidine kinase 2 (TK2). READ MORE

  7. 5. Pharmacological studies on uptake, metabolism, and resistance to anti-cancer drugs : insights into the treatment of leukemia

    Author : Hazhar Karim; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Leukemia is blood cancer that begins in the bone marrow and characterized by abnormal production of white blood cells. Due to advances in treatment, there has been a dramatic increase in survival rate for patients with different types of leukemia. READ MORE