Search for dissertations about: "antibiotic degradation"
Showing result 1 - 5 of 21 swedish dissertations containing the words antibiotic degradation.
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1. Antibiotic Resistance and the Cellular Currency S-adenosyl-methionine : Modification of aminoglycosides and nucleic acids
Abstract : Streptomycin and spectinomycin are antibiotics that bind to ribosomes and inhibit protein synthesis. Common resistance mechanisms involve enzymatic modification of the two drugs by aminoglycoside nucleotidyltransferases (ANTs). The first part of this thesis covers the structural mechanism of two ANT enzymes. READ MORE
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2. Investigation of degradation of toxic substances in fungal cultures by mass spectrometric techniques
Abstract : Micropollutants in water are biological or chemical contaminants that are present in ground and surface waters in trace quantities. They are a result of human activity and include pharmaceutically active compounds (PhACs) and endocrine disrupting compounds (EDCs). READ MORE
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3. Development of phosphorus-containing metallo-β-lactamase inhibitors : Synthesis and binding studies by solution NMR and molecular docking
Abstract : The rapidly growing bacterial resistance development is turning into one of the main challenges of the 21st century. Our antibiotics are becoming ineffective for the treatment of bacterial infections, and without successful action, simple infections, such as pneumonia or Septicemia, will soon carry a highly probable mortal prognosis. READ MORE
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4. Interactions between innate immune effectors and multidrug resistant bacteria
Abstract : Antibiotic resistance is an increasingly difficult problem in the clinic, where conventional antibiotics are failing, and new alternative solutions are in high demand. Infections caused by Gram-negative bacteria with multi drug resistance (MDR) mechanisms are increasing globally, and treatment options are limited. READ MORE
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5. Intracellular systems for characterization and engineering of proteases and their substrates
Abstract : Over the years, the view on proteases as relatively non-specific protein degradation enzymes, mainly involved in food digestion and intracellular protein turnover, has shifted and they are now recognized as key regulators of many biological processes that determine the fate of a cell. Besides their biological role, proteases have emerged as important tools in various biotechnical, industrial and medical applications. READ MORE