Search for dissertations about: "antibody dependent cellular cytotoxicity"

Showing result 21 - 25 of 29 swedish dissertations containing the words antibody dependent cellular cytotoxicity.

  2. 21. Vaccination in gastrointestinal cancer

    Author : Caroline Staff; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CEA;

    Abstract : Advances in immunology have increased the possibility to develop therapeutic cancer vaccines (TCV), as a complementary approach to standard treatment. The goal of a successful cancer vaccine is to induce a potent long-lasting immune response against the tumour with limited toxicity on normal cells. READ MORE

  4. 22. The mast cell transcriptome and the evolution of granule proteins and Fc receptors

    Author : Srinivas Akula; Lars Hellman; Sandra Kleinau; Arne Egesten; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mast cell; Fc receptors; Granule serine protease; Evolution and transcriptome.; Immunologi; Immunology;

    Abstract : Protection against disease-causing pathogens, known as immunity, involves numerous cells organs, tissues and their products. To able to understand the biology of immune cells (hematopoietic cells) and their role in an immune system, we have used several different methods, including transcriptome analyses, bioinformatics, production of recombinant proteins and analyses of some of them, focusing on the granule proteases by substrate phage display. READ MORE

  5. 23. Advancing antiviral strategies against emerging RNA viruses by phenotypic drug discovery

    Author : Marianna Tampere; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pathogenic RNA viruses can emerge from unexpected sources at unexpected times and cause severe disease in humans, as exemplified by the ongoing coronavirus disease 19 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Ebola virus (EBOV), Crimean-Congo hemorrhagic fever virus (CCHFV) and Zika virus (ZIKV) outbreaks from the past decade. Despite the increasing impact of emerging viruses to health and economy worldwide, our preparedness to stand against these diseases is hampered by the lack of approved and effective antiviral therapies. READ MORE

  6. 24. Dynamic shaping of human NK cell receptor repertoires : implications for NK cell-based immunotherapy

    Author : Lisa Liu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Natural killer (NK) cells are innate lymphocytes with a potent intrinsic capacity to kill tumor cells, which makes them attractive candidates for cell-based cancer immunotherapy. Advances during the past decade have revealed that NK cells display a high degree of functional plasticity, suggesting that some subsets may be more effective in targeting cancer cells. READ MORE

  7. 25. Inhibition of apoptosis by the Us3 protein kinase of herpes simplex virus 1

    Author : Anna Cartier; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Us3; unique short 3; HSV; herpes simplex virus; NK; natural killer; LAK; lymphokine activated killer; MHC; major histocompatibility complex;

    Abstract : The Herpes Simplex Virus 1 (HSV-1) US3 protein kinase is part of the anti-apoptotic arsenal that salvage HSV-1-infected cells from damage caused by different stimuli. The Us3 gene encodes a protein kinase that phosphorylates serine/threonine residues within a specific arginine-rich consensus sequence. READ MORE