Search for dissertations about: "antibody elimination"

Showing result 1 - 5 of 28 swedish dissertations containing the words antibody elimination.

2. 1. Factors influencing transferrin receptor-mediated brain delivery : Evaluating preclinical antibody-based proteins for PET imaging in Alzheimer’s disease

   Author : Rebecca Faresjö Melander; Stina Syvänen; Dag Sehlin; Robert Thorne; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; brain delivery; bispecific antibody; transferrin receptor; Alzheimer s Disease; amyloid-beta; aging; single domain antibody; PET; Biofarmaci; Biopharmaceutics; Neurology; Neurologi; Molekylär medicin; Molecular Medicine; Biofarmaci; Biopharmaceutics;

   Abstract : Antibody-based proteins targeting amyloid-beta (Aβ) could be used as radioligands in positron emission tomography (PET) to study Alzheimer’s disease (AD) pathology in the living brain. The prospective advantages of antibody-based PET are to detect pathology earlier, with higher sensitivity, and to evaluate treatment effects of emerging immunotherapies against Aβ. READ MORE

4. 2. Extracorporeal immunoadsorption

   Author : Christian Freiburghaus; Avdelningen för klinisk kemi och farmakologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Klinisk kemi; Clinical chemistry; tolerance induction; inhibitors; haemophilia; Extracorporeal immunoadsorption; antibody elimination; serology; transplantation; Immunologi; serologi;

   Abstract : Antibodies are important protein structures in the immunological defence. Occasionally the regulation of the production of these antibodies fails and antibodies directed against self structures are produced in large scale. Antibody production can also complicate or make transfusions and transplantations impossible. READ MORE

5. 3. Studies on experimental anaerobic infections of the middle ear and on the polymorphonuclear leukocyte function under anaerobic conditions

   Author : Magnus Thore; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Otitismedia; anaerobicbacteria; experimental; nitroimidazoles; antibody; phagocytosis; anaerobiosis;

   Abstract : Despite the clinical importance of anaerobic bacteria in otitis media and the uncertainty regarding the proper treatment of the anaerobic focal infection, few experimental studies focused upon the role of these microorganisms in otitis media have been publis­hed. In the present investigation a guinea-pig model for the induc­tion of anaerobic monoinfections in the middle ear was described. READ MORE

6. 4. Elimination of circulation IgA and IgS immune complexes : An experimental study in mice, rats and guinea pigs

   Author : Anders Johansson; Ann Kari Lefvert; Linköpings universitet; []
   Keywords : MEDICINE; MEDICIN;

   Abstract : Immune complexes were formed between dinitrophenyl- (DNP-) conjugated human serum albumin (HSA) and anti-DNP antibodies (monoclonal mouse IgA or polyclonal rabbit IgG). Blood clearance and tissue distribution of intravenously injected labelled antigen and immunecomplex preparations were studied in mice, rats and guinea pigs. READ MORE

7. 5. Immunity and immunological surveillance for malaria elimination in tropical islands

   Author : Zulkarnain Md Idris; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Malaria remains one of the most significant global public health challenges. Nearly half of the world’s population remains at risk, largely in African Region. In the past decade, considerable progress has been made in the global fight to control and eliminate malaria. READ MORE