Search for dissertations about: "antibody response"

Showing result 1 - 5 of 499 swedish dissertations containing the words antibody response.

2. 1. Antibody Evolution and Repertoire Development

   Author : Johan Lantto; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; virus neutralization; trinucleotide repeat; insertion; immunoglobulin variable genes; human cytomegalovirus; glycoprotein B; deletion; antibody; antibody repertoire;

   Abstract : Antibodies are key players of the immune system in higher vertebrates, which provide a defense against potentially lethal threats from the environment. Besides their importance in the immune defense, antibodies have a great potential as reagents in biological chemistry and diagnostics, and as therapeutic agents against both infectious diseases and cancer. READ MORE

4. 2. Generation and evolution of human antibody repertoires

   Author : Helena Persson; Institutionen för immunteknologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; specificity; Immunology; serology; transplantation; Immunologi; serologi; Biotechnology; Bioteknik; phage display; IgE; hapten; grass pollen allergen; diversity; antibody repertoire; antibody library; antibody evolution; affinity maturation; allergy;

   Abstract : This thesis, which is based on five original papers, covers different aspects of antibody specificity and diversity, with the overall goal to understand the makeup of antibody repertoires and their functionality as they occur in vivo or as they are developed in the laboratory. Besides their importance in the adaptive immune response, antibodies have emerged as an invaluable tool in applications ranging from basic research to disease diagnostics and therapy. READ MORE

5. 3. Antibody-based Cancer Immunotherapy : Personalization, response prediction and safety considerations

   Author : Mohamed Eltahir; Sara Mangsbo; Patrick Micke; Gustav Ullenhag; Marit Inderberg; Uppsala universitet; []
   Keywords : ;

   Abstract : Antibody-based therapeutics have remarkably improved the field of immuno-oncology. Multiple monoclonal antibodies (mAbs) are approved for clinical use, and numerous antibodies are under clinical development. The scope of this thesis is to study the personalization of antibody-based immunotherapeutics and tools to predict their efficacy and safety. READ MORE

6. 4. Production of polyclonal antibodies in rabbits and chickens immunised with human immunoglobulin G : A study of the utility of egg yolk antibody production as a substitute for rabbit serum antibody production

   Author : Lise Svendsen Bollen; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Laboratory animals; antibody production; egg yolk; adjuvants; antibody response; avidity; Försöksdjursvetenskap; Laboratory animal science; Försöksdjursvetenskap; zoologisk utvecklingsbiologi; Animal Development;

   Abstract : The utility of chicken egg yolk antibodies as an alternative to rabbit antisera was studied by comparing antibody and avidity development in immunised animals (15 rabbits and 30 chickens) during a one-year immunisation scheme. Human IgG was used as the model antigen and the efficacy of three adjuvants, Freund's Complete Adjuvant, Freund's Incomplete Adjuvant and Hunter's TiterMax, was compared. READ MORE

7. 5. Antibody Feedback Regulation and T Cells

   Author : Fredrik Carlsson; Birgitta Heyman; Alf Grandien; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fc receptors; B cell; T cell; antigen presentation; complement receptors; complement; IgE; IgG3; CD23; antibody; Immunology; Immunologi;

   Abstract : Antibodies, passively administered or actively produced, regulate immune responses to the antigen they recognize. This phenomenon is called antibody-mediated feedback regulation. Feedback regulation can be positive or negative, resulting in >1000-fold enhancement or >99% suppression of the specific antibody response. READ MORE