Search for dissertations about: "anticancer agent"

Showing result 1 - 5 of 18 swedish dissertations containing the words anticancer agent.

  2. 1. Anticancer Activity of Melflufen : Preclinical Studies of a Novel Peptidase-Potentiated Alkylator

    Author : Sara Strese; Joachim Gullbo; Rolf Larsson; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancertherapy; preclinical studies; melflufen; aminopeptidase-potentiated; cancer; angiogenesis; Klinisk farmakologi; Clinical Pharmacology;

    Abstract : Melflufen (melphalan flufenamide, chemical name L-melphalanyl-p-L-fluorophenylalanine ethyl ester hydrochloride, previously called J1) is a derivative of the classical alkylating agent melphalan. Melflufen is potentiated by hydrolytic cleavage by aminopeptidase N (APN), leading to high intracellular concentrations of alkylating moieties and subsequent cell death. READ MORE

  4. 2. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres

    Author : Lena E Friberg; Mats Karlsson; Alan Boddy; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI; farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

    Abstract : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. READ MORE

  5. 3. Reactions of Model and Anticancer Active Platinum(IV/II) Complexes - A Kinetic and Mechanistic Study

    Author : Kelemu Lemma; Kemiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Model Pt II complexes; Anticancer active Pt IV compounds; Cisplatin; Rescue agents; L-Ascorbic acid; Thiol; Substitution; Kinetics and mechanism; Electron transfer; Inorganic chemistry; Oorganisk kemi;

    Abstract : In this thesis reductions of model and anticancer active Pt(IV) complexes with thiols and ascorbic acid and substitution reactions of cisplatin and model Pt(II) complexes with S-donor nucleophiles (rescue agents) have been investigated using stopped-flow and UV/VIS spectrophotometry. Glutathione (GSH) reduction of the anticancer active Pt(IV) compounds t- and c-[PtCl4(cha)(NH3)] (cha = cyclohexylamine), t-[PtCl4(thiazole)(NH3)] and c-[PtCl4(NH3)2] at 25 oC was observed to be very fast. READ MORE

  6. 4. On the role of different signal transduction pathways in induction of apoptosis by anticancer drugs

    Author : Maria Berndtsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Anticancer drug treatment gives rise to complex cellular responses in tumor cells. An improved understanding of the mechanisms underlying these responses is important in order to improve treatment. It is also of importance to investigate novel mechanisms of drug action that could potentially represent new concepts for treatment. READ MORE

  7. 5. Studies on ribonucleotide reductase, a target for anticancer therapy, with focus on electron donor aspects : thioredoxin and glutaredoxin systems

    Author : Farnaz Zahedi Avval; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Faithful replication of DNA and its repair are fundamental processes in all living cells which utilize deoxyribonucleotides as DNA building blocks. Ribonucleotide reductase (RNR) is the essential enzyme for de novo synthesis of these precursors from ribonucleoside diphosphates. READ MORE