Search for dissertations about: "anticancer study"

Showing result 11 - 15 of 64 swedish dissertations containing the words anticancer study.

  2. 11. Plurifaceted proteomics in studying cellular dynamics and action mechanisms of anticancer drugs

    Author : Pierre Sabatier; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mass spectrometry (MS)-based proteomics has developed tremendously in recent years and was the leading technology for many novel methods to study protein chemistry. Contrary to classical approaches based on Western blot, MS-based approaches are mostly unbiased. READ MORE

  4. 12. Pharmacometric Models for Biomarkers, Side Effects and Efficacy in Anticancer Drug Therapy

    Author : Emma K. Hansson; Lena Friberg; Mats O Karlsson; Charlotte Kloft; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics; Pharmacodynamics; Oncology; Febrile Neutropenia; GIST; Sunitinib; PHARMACY; FARMACI; Pharmacokinetics and Drug Therapy; Farmakokinetik och läkemedelsterapi;

    Abstract : New approaches quantifying the effect of treatment are needed in oncology to improve the drug development process and to enable treatment optimization for existing therapies. This thesis focuses on the development of pharmacometric models for biomarkers, side effects and efficacy in order to identify predictors of clinical response in anti-cancer drug therapy. READ MORE

  5. 13. Studies of Intracellular Transport and Anticancer Drug Action by Functional Genomics in Yeast

    Author : Marie Gustavsson; Hans Ronne; Anders Blomberg; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; 5-fluorouracil; tRNA modifications; Saccharomyces cerevisiae; carbamoyl phosphate synthase; V-ATPase; Functional genomics; Funktionsgenomik;

    Abstract : This thesis describes the use of functional genomics screens in yeast to study anticancer drug action and intracellular transport. The yeast Saccharomyces cerevisiae provides a particularly useful model system for global drug screens, due to the availability of knockout mutants for all yeast genes. READ MORE

  6. 14. Prediction of side effects from anticancer treatment with the purpose of increasing quality of life

    Author : Delmy Oliva; Freddi Lewin; Charlotta Dabrosin; Lena Sharp; Lasse D Jensen; Eva Brun; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Cancer and its treatments can cause a variety of symptoms. Some of these symptoms are related to the disease and others are seen as a consequence of the treatment. Since patients experience side effects to different degrees despite undergoing the same treatment, it is hypothesized that there is a genetic factor. READ MORE

  7. 15. Mammalian thioredoxin reductase 1 in antioxidant defense, regulation of adipocyte differentiation and as an anticancer drug target

    Author : Xiaoxiao Peng; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Reactive oxygen species (ROS) are oxygen containing reactive molecules generated as by-products of cellular metabolism. At physiological concentrations, ROS acts as secondary messengers in cellular signaling transduction, but excessive amounts of ROS result in oxidative stress and cellular damage. READ MORE