Search for dissertations about: "anticancer study"

Showing result 16 - 20 of 64 swedish dissertations containing the words anticancer study.

  2. 16. Anticancer drug treatment in pediatric patients : studies on optimizing dosage and on parental guidance for improved drug handling at home

    Author : Ranaa Akkawi el Edelbi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Background: Every year about 370 children are diagnosed with cancer in Sweden. The treatment includes both inpatient and outpatient care with anticancer drugs. At the clinic, the optimal anticancer drug dosage is usually derived from the patient’s body surface area (BSA). READ MORE

  4. 17. Cloning and characterization of human deoxyribonucleoside kinases : phosphorylation of anti-cancer and anti-viral nucleoside analogs

    Author : Magnus Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : deoxyribonucleoside kinase; nucleoside analog; deoxycytidinekinase; deoxyguanosine kinase; thymidine kinase 1; thymidine kinase 2; deoxyribonucleosidephosphorylation; deoxyribonucleotides; anticancer therapy; antiviral therapy;

    Abstract : Deoxyribonucleoside kinases catalyze the phosphorylation of deoxyribonucleosides to deoxyribonucleoside monophosphates. There are four major deoxyribonucleoside kinasesin human cells: thymidine kinase 1 (TKl), deoxycytidine kinase (dCK), deoxyguanosinekinase (dGK), and thymidine kinase 2 (TK2). READ MORE

  5. 18. Terpenoid Plant Metabolites - Structural Characterization and Biological Importance

    Author : Eliana Maldonado; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Terpenoid Sesquiterpene lactones Breast-cancer cell lines Cytotoxicity Antileishmanicial Structural characterization;

    Abstract : In response to the challenges of their local environments, organisms produce of a large number of chemical diverse compounds with complex stereochemistry and reactive functional groups. These characteristics enable them to interact and bind specifically to biological target molecules and exert various biological activities, and have assured that Natural products continues to be an important source of bioactive compounds, which, for example, facilitate the search for new lead structures that can be developed into new pharmaceuticals. READ MORE

  6. 19. Analysis of drugs and proteins in biological matrices, using different types of sample preparations and mass spectrometry

    Author : Aljona Saleh; Ingrid Granelli; Jonas Bergquist; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioanalysis; drugs; proteins; liquid chromatography; two-dimensional liquid chromatography; mass spectrometry; Analytical Chemistry; analytisk kemi;

    Abstract : This thesis describes bioanalysis of small and large molecules in biological matrices and includes screening of illegal drugs in urine with high resolution mass spectrometer, bioanalysis of MTH1 inhibitors in mice plasma and quantification of proteins in plasma and cell lysates.Screening of illegal drugs was based on high resolving power mass spectrometer (QTOF) and the results were compared to immunoassays. READ MORE

  7. 20. Deciphering Ephrin/Eph signaling pathways in cancer cells using rationally designed ligand nanoclusters

    Author : Alan Shaw; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The dynamic link between the nanoscale spatial distribution of biomolecules and their functional impact on cellular and downstream biological behaviors has been hypothesized, but only supported by limited evidences. This is mostly due to the lack to methods to fabricate well-defined patterns of biomolecules. READ MORE