Search for dissertations about: "anticancer therapy"

Showing result 1 - 5 of 55 swedish dissertations containing the words anticancer therapy.

  2. 1. Mitochondria : a target for anticancer therapy

    Author : Björn Kruspig; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mitochondria possess a central role in several cellular metabolic pathways, maintenance of calcium homeostasis, production of reactive oxygen species (ROS) and in the regulation of various cell death modalities. A majority of cancers demonstrate aberrations in mitochondrial functions, which were shown to contribute to tumourigenesis. READ MORE

  4. 2. The role of autophagy in anticancer therapy

    Author : Matheus Dyczynski; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Autophagy is a fundamental catabolic process, which is utilized by nearly every cell and tissue type upon stress exposure and has been shown to contribute to resistance to chemotherapy in a variety of cancers. The subject of this thesis is to shed light on the role of autophagy in chemotherapy and to investigate novel regulators of autophagy. READ MORE

  5. 3. Pharmacometrics for Combination Therapy in Oncology Within and Across Species Variability in Time Series and Time-to-event Data

    Author : Marcus Baaz; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mathematical Modeling; Pharmacometrics; Nonlinear Mixed Effects; Oncology; Combination Therapy; Radiation Therapy;

    Abstract : Mathematical modeling is an integral part of the drug development process. Models are developed to describe tumor dynamics or drug concentration to answer questions such as: What concentration is required to reach the desirable treatment outcome? What drug dose and frequency should a drug prescription specify to achieve this concentration? Models are also used for simulation, reducing the need to perform additional animal trials. READ MORE

  6. 4. Data-driven modeling of combination therapy in oncology

    Author : Tim Cardilin; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Model-Based Drug Development; Pharmacokinetics Pharmacodynamics; Nonlinear Mixed-Effects Models; Combination Therapy; Mathematical Modeling; Nonlinear Mixed-Effects Models;

    Abstract : This thesis contains two manuscripts: Tumor Static Concentration Curves in Combination Therapy and Extending the Tumor Static Concentration Curve to Exposure - A Combination Therapy Example with Radiation Therapy. There is also an introductory chapter presenting some basic facts necessary to understand the appended manuscripts. READ MORE

  7. 5. Cytochrome P450 pharmacogenetics : implications for anticancer and warfarin therapy

    Author : Mi-Young Lee; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : There is a pronounced interindividual variability in the drug disposition, response and toxicity. Pharmacogenetics aims at identifying genetic biomarkers that could help to increase the drug efficacy, reduce adverse drug reactions and contribute to the development of personalized medicine. READ MORE