Search for dissertations about: "antiepileptic"

Showing result 1 - 5 of 51 swedish dissertations containing the word antiepileptic.

  2. 1. Common mechanism for teratogenicity of antiepileptic drugs : Drug-induced embryonic arrhythmia and hypoxia-reoxygenation damage

    Author : Faranak Azarbayjani; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Atiepileptik drugs; embryonic heart; arrhythmia; cleft palate; ROS; antioxidants; Ikr; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Toxicology; toxikologi;

    Abstract : The Antiepilptic drugs (AEDs) phenytoin (PHT), carbamazepine (CBZ), phenobarbital (PB), tri- and dimethadione (TMD and DMD) are known teratogens having a common malformation pattern in human and animal studies. This thesis was designed chiefly to test a hypothesis correlating the teratogenicity of these AEDs to episodes of pharmacologically induced embryonic arrhythmia and hypoxia-reoxygenation damage. READ MORE

  4. 2. The informational value and usefulness of serum retinoid measurements. Studies on biological variation, including infancy and pregnancy, and influence of fasting, antiepileptic drugs and ethanol

    Author : Maria Berggren Söderlund; Avdelningen för klinisk kemi och farmakologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Klinisk kemi; Clinical chemistry; vitamin A deficiency; teratogenicity; ethanol; antiepileptic drugs; caloric restriction; infant; pregnant; biological variation; 13-cis retinoic acid; all-trans retinoic acid; Vitamin A; retinol;

    Abstract : The aims of these studies were to evaluate retinoid measurements, more specifically the performance of all-trans and 13-cis retinoic acids methods in clinical experimental settings and to evaluate the informational value of these measurements in relation to S-Retinol. Biological and analytical variations for retinoids were evaluated for healthy subjects. READ MORE

  5. 3. Monitoring of antiepileptic drugs using microdialysis : methodological and clinical aspects

    Author : Martin Lindberger; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In therapeutic monitoring of antiepileptic drugs (AEDs) the level of unbound drug at the sampling site should ideally equal the unbound concentration at receptor sites. Microdialysis enables direct sampling of the unbound drug concentration and avoids some of the difficulties encountered with ex vivo protein binding. READ MORE

  6. 4. Living with epilepsy : young people with uncomplicated epilepsy and adults with newly debuted epilepsy

    Author : Lena Räty; Matti Sillanpää; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adolescence; antiepileptic drug; attitude; epilepsy; health; self-concept; self-esteem; seizure type; seizure control; sense of coherence; quality of life; MEDICINE; MEDICIN; Nursing Science;

    Abstract : The aim of this thesis was to illuminate experiences of living with uncomplicated epilepsy, i.e. epilepsy without any associated neurological impainnents. The focus was on young people, aged 13- 22 (II, III, IV), and adults, aged 18-65 (I), with newly debuted epilepsy, i. READ MORE

  7. 5. Epilepsy in young adulthood : medical, psychosocial and functional aspects

    Author : Helena Gauffin; Anne-Marie Landtblom; Birgitta Söderfeldt; Maria Engström; Thomas Karlsson; Lena Räty; Elinor Ben-Menachem; Linköpings universitet; []
    Keywords : Epilepsy; young adult; Quality of Life; self-esteem; daily life; antiepileptic drugs; cognition; language; fMRI; Sence of Coherence;

    Abstract : The aim of this thesis was to describe the medical, cognitive and psychosocial consequences of epilepsy in young adulthood. Four studies were carried out with this patient group. READ MORE