Search for dissertations about: "antiestrogen"
Showing result 1 - 5 of 7 swedish dissertations containing the word antiestrogen.
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1. Molecular mechanisms of estrogen and antiestrogen action
Abstract : Estrogen is a key regulatory hormone that affects numerous physiological processes. The estrogen receptors (ER), ER alpha and ER beta, play a central role in mediating the effects of both estrogens and antiestrogens. Estrogen signaling has proven to be multifaceted and the precise mechanism of action remains in many cases elusive. READ MORE
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2. Analysis of DNA adducts formed by tamoxifen and related antiestrogenic and estrogenic compounds in rats
Abstract : The work presented herein has focused on DNA adduct formation by the non-steroidal antiestrogen tamoxifen and its analogues. Tamoxifen, [(Z)-1-{4-[2-(dimethylamino)-ethoxy]phenyl}-1,2-diphenyl-1-butene], is widely used in the treatment of breast cancer and its recognised side effect is endometrial cancer. READ MORE
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3. Estrogen receptor b in the urogenital tract of both male and female
Abstract : The central finding of this thesis is that estrogen receptors regulate androgen receptor expression: ERalpha unpregulates AR and ERbeta down-regulates AR. With this theme, we explored the physiological role of an ER-AR pathway, especially ERbeta-AR, in some urogenital tissues, uterus, ovary and prostate, using ERbeta knockout mice. READ MORE
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4. Biochemical and Structural Studies on the Adaptor Protein p130Cas
Abstract : Crk associated substrate (Cas) is an adaptor protein that becomes phosphorylated upon integrin signaling and influences regulation of cell processes such as migration, proliferation and survival. It consists of multiple domains and regions that can interact with several signaling proteins involved in different signaling pathways. READ MORE
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5. Hormonal regulation of hepatic cholesterol and lipoprotein metabolism : effects of estrogen and growth hormone
Abstract : Coronary heart disease is the result of the progression of atherosclerotic lesions, and represents the major cause of death in western countries. Age, male sex, plasma cholesterol, hypertension and smoking are major risk factors for atherosclerosis. READ MORE