Search for dissertations about: "antigenic shift"

Found 5 swedish dissertations containing the words antigenic shift.

2. 1. Influenza A Virus : Spatial analysis of influenza genome trafficking and the evolution of the neuraminidase protein

   Author : Dan Dou; Robert Daniels; Martin Schwemmle; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Influenza A virus; IAV; neuraminidase; NA; IAV genome trafficking; viral entry; viral replication; co-infection; antigenic drift; antigenic shift; NA assembly; transmembrane domain; evolution; Biochemistry; biokemi;

   Abstract : Influenza A viruses (IAVs) are a common infectious agent that seasonally circulates within the human population that causes mild to severe acute respiratory infections. The severity of the infection is often related to how the virus has evolved with respect to the pre-existing immunity in the population. READ MORE

4. 2. Computational Analysis of Carbohydrates : Dynamical Properties and Interactions

   Author : Robert Eklund; Göran Widmalm; Sören B. Engelsen; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Carbohydrate; DFT; ab initio; docking calculations; Molecular dynamics; Langevin Dynaimcs; structure analysis; carbohydrate-protein interaction; Chemical shift calculations; Spin spin coupling constants.; Organic chemistry; Organisk kemi;

   Abstract : In this thesis a computational complement to experimental observables will be presented. Computational tools such as molecular dynamics and quantum chemical tools will be used to aid in the interpretation of experimentally (NMR) obtained structural data. READ MORE

5. 3. Variable viral genes as genetic immunogens

   Author : Karl Ljungberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Influenza; hemagglutinin; HIV-1; gp160; DNA vaccine; genetic immunization; CpG; GM-CSF; pseudovirus.;

   Abstract : Influenza and HIV-1 are two highly variable viruses that cause extensive morbidity and mortality in many countries. The most cost-effective medical intervention against influenza is vaccination but this has to be repeated annually because of the low antigenicity of the vaccine. READ MORE

6. 4. Viruses on the wing : evolution and dynamics of influenza A virus in the Mallard reservoir

   Author : Michelle Wille; Jonas Waldenström; Timm Harder; Linnéuniversitetet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Co-infections; Ecology; Epidemiology; Evolution; Host-Parasite Interactions; Immunity; Influenza A Virus; Mallard; Phylogeny; Virology; Waterfowl; Wild Birds; Wildlife Disease; Zoonotisk ekologi; Zoonotic Ecology;

   Abstract : This thesis explores the evolution of avian influenza A viruses (IAV), as well as host-pathogen interactions between these viruses and their main reservoir host, the Mallard (Anas platyrhynchos). IAV is a genetically diverse, multi-host virus and wild birds, particularly dabbling ducks, are the natural reservoir. READ MORE

7. 5. HIV-1 variability in relation to host defence mechanisms and disease outcome

   Author : Marianne Jansson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : HIV-1; peptides; seroreactivity; genetic variability; pediatric; disease outcome; biological phenotypes; B-chemokines; coreceptors; V3; V2.;

   Abstract : Genetic variability is a major characteristic of HIV-1. Virus variants evolve rapidly, not only globally, but also within single individuals as a result of an error-prone reverse transcriptase, a rapid virus population turnover and selective pressure from the host. READ MORE