Search for dissertations about: "antigenic variation"

Showing result 21 - 25 of 28 swedish dissertations containing the words antigenic variation.

  2. 21. Contribution of the outer surface proteins of Borrelia burgdorferi s.l. to the pathogenesis of Lyme disease

    Author : Maria Jonsson; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Borrelia burgdorferi; Lyme disease; Osp proteins; ospAB operon; gene regulation; pathogenicity;

    Abstract : Borrelia burgdorferi s. l. is a spirochete which causes the multisystemic disorder Lyme disease. As the borreliae lack toxin production, the pathogenicity is thought to involve, at least in part, molecules from the outer surface. READ MORE

  4. 22. Biomolecular characterization of mumps virus genotypes with varying neurovirulence

    Author : Tesfaldet Tecle; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mumps virus is an RNA virus, which belongs to the Rubula virus genus of the family Paramyxoviridae. Mumps is a common childhood infection. Classically, mumps infection presents as parotitis although it is frequently asymptomatic in young children. READ MORE

  5. 23. Streptococcal protein Rib and related proteins: a family of repetitive surface proteins that elicit protective immunity

    Author : Margaretha Stålhammar-Carlemalm; Institutionen för laboratoriemedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiology; cross-protection; epithelial cell adhesion; protective immunity; vaccination; surface proteins; Group B streptococcus; Streptococcus pyogenes; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Abstract : ABSTRACT Streptococci constitute a heterogeneous group of Gram-positive bacteria, divided into different serological groups on the basis of antigenic differences in a cell wall-associated carbohydrate. This thesis describes related surface proteins expressed by bacteria in two of these groups, the group B streptococcus (GBS) and the group A streptococcus (GAS). READ MORE

  6. 24. Functional and genetic analyses of the MHC and its impact on autoimmunity in the rat

    Author : Jonatan Tuncel; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The major histocompatibility complex (MHC) is an allele-rich and exceptionally gene dense region on human chromosome 6. Over 40% of the genes in this region have immune-related functions, including genes encoding MHCI and MHCII molecules. These molecules, which are found in nearly all vertebrates, present antigenic peptides to CD4 and CD8 T cells. READ MORE

  7. 25. Genomic feature identification in trypanosomatid parasites

    Author : Daniel Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Trypanosoma cruzi; genome sequence; bioinformatics; gene finding; Trypanosoma brucei; Leishmania major; strand asymmetry; trans splicing; polyadenylation; post-transcriptional control; uAUGs.;

    Abstract : The trypanosomatid parasites cause death and suffering, among humans as well as livestock. Current drugs lack efficacy and cause severe side effects, and no vaccines are available. Increased knowledge of the biology of the parasites is vital for the development of new drugs. READ MORE