Search for dissertations about: "antigenicity"

Showing result 1 - 5 of 21 swedish dissertations containing the word antigenicity.

  2. 1. Selection and design in antibody phage display

    Author : Jonas Persson; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; specificity fine-tuning.; phage display; MUC1; automated selection; antigenicity; antibody; affinity maturation;

    Abstract : The immune system is an important part of the physiology of higher organisms. In the immune system antibodies play a key role in neutralizing and clearing potentially lethal threats from the environment. The importance of antibodies in the immune system has made them come to the attention as a tool in chemistry and medicine. READ MORE

  4. 2. Glycoprotein G of Herpes simplex virus type 2. Antigenicity and genetic variability

    Author : Jan-Åke Liljeqvist; Göteborgs universitet; []
    Keywords : Herpes simplex virus type 2; glycoprotein G; antigenic regions; sequence variability;

    Abstract : Herpes simplex virus type 2 (HSV-2) causes genital lesions, meningitis and occasionally, severe neonatal infections. Globally HSV-2 infection is one of the most common sexually transmitted diseases. READ MORE

  5. 3. Autoantigenic properties of the U1-70K protein

    Author : Elisabet Welin Henriksson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : U1-70K protein; ribonucleoproteins; autoantigens; autoantibodies; epitopemapping; connective tissue disease; species specificity; cross reactions; amino acidsequence; recombinant proteins; mutagenesis;

    Abstract : Patients with the autoimmune diseases systemic lupus erythematosus and mixed connective tissue disease produce autoantibodies directed towards specific groups of cellular constituents in their own body. Two of the targeted antigens are denoted Sm and RNP, and consist of distinct collections of splicing associated RNA-protein complexes. READ MORE

  6. 4. Humoral and cellular immune responses to proteins encoded by the hepatitis C virus

    Author : Zhu-Xu Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HCV; genotype; antibody; IFN-alpha; MHC; haplotype; ScFv; peptide; T cell;

    Abstract : The hepatitis C virus (HCV) was the first described human pathogen of the hepaciviruses, a new genus within the flaviviridae family. A characteristic feature of HCV is that it has a high genetic heterogenecity. It is believed that the immune response is of vital importance to prevent, control, and to eradicate HCV infections. READ MORE

  7. 5. Causes of Substitution Frequency Variation in Pathogenic Bacteria

    Author : Wagied Davids; Siv Andersson; Otto Berg; Bengt Persson; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Comparative genomics; Molecular evolution; Bioinformatics; Human pathogens; Rickettsia; Helicobacter pylori; Biologi; Biology; Biologi;

    Abstract : Estimating substitution frequencies at sites that influence (Ka) and do not influence (Ks) the amino acid sequence is important for understanding the dynamics of molecular sequence evolution and the selective pressures that have shaped genetic variation. The aim of this work was to gain a deeper understanding of the driving forces of substitution frequency variation in human pathogens. READ MORE