Search for dissertations about: "antimalarial drugs"

Showing result 16 - 20 of 40 swedish dissertations containing the words antimalarial drugs.

  2. 16. Half-sandwich complexes with amino-quinoline ligands - synthesis, antiplasmodial and antimycobacterial activities

    Author : Erik Ekengard; Kemisk fysik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; malaria; tuberculosis; half-sandwich compound; drug-resistance; bioorganometallic chemistry;

    Abstract : Malaria and tuberculosis are two of the most deadly infectious diseases that exist. Both diseases predominantly affect the most vunerable parts of society. Additionally the treatment of both diseases are complicated by growing and spreading resistance against the drugs used to treat them. READ MORE

  4. 17. Cytochrome P450 enzymes affected by artemisinin antimalarials-pharmacokinetic and pharmacogenetic aspects

    Author : Sara Asimus; Göteborgs universitet; []
    Keywords : artemisinin; autoinduction; cytochrome P450; induction; inhibition; malaria; metabolism; pharmacogenetics; pharmacokinetics; probe;

    Abstract : With more than 500 million cases and at least 1 million deaths each year, malaria is a major global health problem. The main problem with malaria control is the emerging drug resistance among parasites causing the infection. Consequently, there is an urgent need for new drugs. READ MORE

  5. 18. Pharmacokinetic drug-drug interactions in the management of malaria, HIV and tuberculosis

    Author : Doaa Elsherbiny; Ulrika Simonsson; Mats Karlsson; Lars Ståhle; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Drug-drug interactions; Cytochrome P-450; Artemisinin antimalarials; Nevirapine; Lopinavir; Rifampicin; NONMEM; Farmakokinetik Farmakoterapi;

    Abstract : Malaria, Human Immunodeficiency Virus (HIV) and tuberculosis (TB) are global health problems having their worst situation in sub-Saharan Africa. Consequently, concomitant use of antimalarial, antiretroviral and antitubercular drugs may be needed, resulting in a potential risk of drug-drug interactions. READ MORE

  6. 19. CYP2C19 catalyzed drug metabolism in different populations

    Author : Karin Herrlin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CYP2C19; drug metabolism; cytochrome P450; mephenytoin; omeprazole; proguanil chloroguanide ; citalopram; debrisoquine; CYP2D6; gene duplication; pharmacogenetics;

    Abstract : Metabolism catalyzed by the cytochrome P450 enzyme CYP2C19 varies between individuals, who can be either efficient (EM) or poor metabolizers (PM). In this thesis the metabolism of four different CYP2C19 substrates (citalopram, mephenytoin, omeprazole, and proguanil) was investigated in vivo in Africans (Ethiopians an Tanzanians) an in Swedish is Caucasians. READ MORE

  7. 20. Improved malaria case management in under-fives in the era of Artemisinin-based combination therapy in Tanzania

    Author : Billy Ephraim Ngasala; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Malaria microscopy; case management; efficacy; effectiveness; artemether-lumefantrine; retreatment; lumefantrine concentrations; randomized trial; Tanzania;

    Abstract : Early parasite-based diagnosis of malaria prior to treatment is critical for rational drug use, optimal outcome of febrile illness, patient adherence, prevention of parasite drug resistance, and reduced costs of health services. However, most primary health care (PHC) facilities in sub-Saharan Africa have no laboratory support and malaria diagnosis is based on clinical symptoms and signs, which are nonspecific. READ MORE