Search for dissertations about: "antimalarial drugs"

Showing result 21 - 25 of 40 swedish dissertations containing the words antimalarial drugs.

  2. 21. Drug Analysis : Bioanalytical Method Development and Validation

    Author : Mikaela Malm; Yngve Bergqvist; Anders Colmsjö; Uppsala universitet; []
    Keywords : Analytical chemistry; African trypanosomiasis; calibration model; chiral chromatography; dried blood spots; eflornithine; evaporative light-scattering detection; HIV AIDS; lamivudine; liquid chromatography; malaria; nevirapine; piperaquine; pneumonia; solid-phase extraction; sulfadoxine; sulfamethoxazole; validation; zidovudine; Analytisk kemi;

    Abstract : This thesis describes bioanalytical methods for drug determination in biological matrixes, with drugs in focus used against diseases largely affecting low-income countries. Solid-phase extraction is used for sample cleanup, and processed samples are analyzed by liquid chromatography. READ MORE

  4. 22. Polyamine Pathway as Drug Target against Malaria

    Author : Janina Sprenger; Biogena aminer; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amino acid insertions; Crystallography; polyamine pathway; drug design; enzyme inhibition; ITC; ligand binding; malaria; Plasmodium falciparum; S-Adenosylmethionine decarboxylase; spermidine synthase.;

    Abstract : Malaria, caused by the protozoan parasite Plasmodium falciparum is responsible for about 600.000 death cases every year. Mainly affected are populations of subtropical countries in Africa and the largest groups of victims are children below the age of 5 years. READ MORE

  5. 23. In vitro and in vivo studies of artemisinin endoperoxides

    Author : Therese Ericsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Artemisinin; Artesunate; Breast cancer; Cytochrome P450; Dihydroartemisinin; Inhibition; LC-MS MS; Pharmacokinetics; Plasma; Saliva;

    Abstract : Artemisinin and its semi-synthetic derivatives (eg. Artemether/ARM, artesunate/ARS, dihydroartemisinin/DHA) play an important role in combating malaria, and treatments containing an artemisinin derivative (artemisinin-based combination therapies, ACTs) are today the standard treatment worldwide for Plasmodium falciparum malaria. READ MORE

  6. 24. Molecular basis for the mechanism of action and resistance to artemisinin combination therapy in Plasmodium falciparum

    Author : Pedro Ferreira; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum;

    Abstract : Malaria, caused by the Plasmodium falciparum parasite, remains a leading cause of death among children in Africa. To improve treatment efficacy and delay development and spread of antimalarial drug resistance artemisinin artemisinin-based combination therapy (ACT) is now globally recommended as first-line treatment of uncomplicated P. READ MORE

  7. 25. In Vitro Studies of Factors Potentially Affecting Plasmodium Falciparum Infection : (Heparin and Anti-P. falciparum Immune Responses)

    Author : Asli Kulane; Birthe Högh; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Immunology; Immunologi; immunologi; Immunology;

    Abstract : Plasmodium falciparum malaria is considered one of the major infectious diseases in humans, with regard to mortality and morbidity. Growing resistance of malaria to most anti-malaria drugs and of the Anopheles mosquitoes to insecticides have resulted in a global resurgence of the disease. READ MORE