Search for dissertations about: "antineoplastic agents"
Found 5 swedish dissertations containing the words antineoplastic agents.
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1. Antibiotics in patients on chemotherapy; aspects on pharmacokinetic and pharmacodynamic interactions with antineoplastic drugs
Abstract : The aims of these studies were to investigate the pharmacokinetics of two beta-lactam antibiotics in patients with fever and cytostatic-induced neutropenia and the influence of cytostatic-induced gastrointestinal damage on the absorption of co-trimoxazole. Furthermore to study the pharmacodynamic interactions between antibiotics and antineoplastic drugs and the impact of antineoplastic drugs on the intestinal microflora. READ MORE
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2. Cellular toxicity of quinones : Redox- and addition chemistry
Abstract : Quinoid compounds are widely occurring in nature. They have cytotoxic properties and they are also used as antineoplastic agents. The cytotoxic properties can be explained by the ability of quinones to generate active oxygen species by redox cycling, by addition to cellular nucleophiles, and by inhibition of DNA transcription. READ MORE
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3. Polyamine analogues inhibit neuroblastoma cell growth
Abstract : Abstract Neuroblastoma is a highly malignant neoplasm found in children. Although children with high-risk neuroblastoma respond to chemotherapy, relapses are common and an estimated long-time survival prognosis is approximately 15%. Thus, there is a tremendous need for new chemotherapeutic drugs for the treatment for neuroblastoma. READ MORE
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4. Studies of overcoming acquired resistance : molecular mechanisms and development of novel drugs
Abstract : Chemotherapeutic agents have become widely applied for treatment of various types of malignancies. Drug resistance unfortunately remains as a major obstacle for the effectiveness of chemotherapy. Cancer drug resistance includes two broad categories: intrinsic and acquired. READ MORE
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5. Aetiology and infection susceptibility in neutropaenic patients
Abstract : Increasingly intensive antineoplastic regimes have been effective in the treatment for haematological malignancies, but as effective as it is in limiting neoplasm of the malignant cells, bystander damage occurs equally to cells of the immune system and epithelial cells of the mucosa. Infectious complications following chemotherapy reflect this situation. READ MORE