Search for dissertations about: "antioxidant defense"

Showing result 11 - 15 of 26 swedish dissertations containing the words antioxidant defense.

  2. 11. Glutathione in the brain. Studies on efflux and possible implications in neurotoxicity

    Author : Camilla Wallin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glutathione; excitotoxicity; hypoxia-ischemia; brain; rat; anoxia-aglycemia; g-glutamyl transpeptidase; glutamate; NMDA; oxidative stress; mitochondria; amino acids;

    Abstract : Neuronal cell death in acute insults such as stroke, trauma and epilepsy involves overactivation of glutamate receptors, calcium influx and increased formation of potentially toxic reactive oxygen species. Glutathione is a key component in the antioxidant defense system against reactive oxygen species. READ MORE

  4. 12. Myocardial protection by hyperoxia

    Author : Peeter Tähepõld; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Oxygen is essential for normal respiration in aerobic organisms, and prolonged deficit of oxygen always has detrimental consequences.However, all aerobic life forms are faced with the threat of oxidation from molecular oxygen. READ MORE

  5. 13. CRISPR Screens Identify Candidate Therapeutic Targets in Leukemia

    Author : Maria Rodriguez Zabala; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; CRISPR screen; leukemia stem cell; cell surface receptor; metabolism; immunotherapy; CXCR4; GLUT1; TFR1; H2-K1;

    Abstract : Acute myeloid leukemia (AML) is a complex hematological malignancy marked by proliferation of immature myeloid cells with a dismal 5-year survival. A major challenge is the persistence of leukemia stem cells (LSCs) after standard treatment, leading to relapse. READ MORE

  6. 14. Astrocytic communication and cell death during metabolic depression and oxidative stress

    Author : Christina Nodin; Göteborgs universitet; []
    Keywords : astrocyte; gap junction; ATP; ROS; oxidative stress; Annexin V; AIF; programmed cell death; Nrf2; scavenger; iodoacetate; SIN-1;

    Abstract : Stroke is a major cause of death and adult disability in the western world. Most often, stroke is caused by the occlusion of a brain artery. Within the perfusion territory of the occluded vessel, various degrees of necrotic and delayed programmed cell death will occur if the occlusion persists, leading to expanding tissue damage. READ MORE

  7. 15. Adult neural stem cells and their differentiation choices : examples from experimental inflammation and transplantation

    Author : Cynthia Pérez Estrada; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this thesis is to study how inflammation influences the fate of NPCs, which can impact the regenerative capacities of the CNS. In paper I, we used a hypoglossal nerve avulsion model, to study if survival, differentiation, and integration of transplanted NPCs could be achieved. READ MORE