Search for dissertations about: "antioxidant defense"

Showing result 21 - 25 of 26 swedish dissertations containing the words antioxidant defense.

  2. 21. Molecular and Functional Dynamics of Hematopoietic Progenitor Cell Fate During Ontogeny

    Author : Maria Jassinskaja; Proteomisk hematologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hematopoies; developmental hematopoiesis; Proteomics; Leukemia; Mass Spectrometry;

    Abstract : Hematopoietic stem and progenitor cells (HSPCs) in the fetus and the adult possess distinct molecular signatures that regulate cell fate and change their susceptibility to initiation and progression of hematological malignancies, such as leukemia. It is well established that fetal and adult hematopoiesis are functionally distinct processes; however, the underlying molecular mechanisms that govern ontogenic differences in normal and malignant hematopoiesis have thus far been poorly explored on the proteomic level. READ MORE

  4. 22. Exploring thioredoxin reductase as an anticancer drug target

    Author : Stefanie Prast-Nielsen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Mammalian thioredoxin reductase (TrxR; EC 1.8.1.9) is a homodimeric NADPH-dependent selenium-containing flavoenzyme with disulfide oxidoreductase activity. READ MORE

  5. 23. Local pharmacological treatment of inner ear disorders

    Author : Cecilia Engmér Berglin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hearing disorders are among the top 10 in terms of burden of disease in middle- and high-income countries, affecting 250 million people worldwide. During the last few decades researchers have made significant advances in understanding the basic mechanisms and molecular biology of inner ear diseases. READ MORE

  6. 24. Air pollution, genetic susceptibility and inflammation : focusing on cardiovascular effects in adults and respiratory effects in children

    Author : Sviatlana Panasevich; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Air pollution exposure can induce low-grade systemic inflammation with consequences for both cardiovascular and respiratory systems. The overall aim of this thesis was to investigate the effects of air pollutants on the development of complex inflammatory diseases (myocardial infarction and respiratory disease), and genetically determined susceptibility for these effects, using epidemiologic methodology. READ MORE

  7. 25. The use of protein biomarkers in ecotoxicology : Studies of oxidative and genotoxic stress in the blue mussel (Mytilus edulis)

    Author : Andreas Prevodnik; Michael Tedengren; Tomas Bollner; Kari Lehtonen; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Biologi; Ecotoxicology; ekotoxikologi;

    Abstract : Many environmental pollutants, heavy metals and polyaromatic hydrocarbons (PAHs) among them, are toxic by oxidative stress. Oxidative stress may be defined as a state in an organism when its inherent capacity to handle oxyradicals is surpassed, and it may result in peroxidation of lipids, and damage to proteins and DNA. READ MORE