Search for dissertations about: "antiproliferative"

Showing result 11 - 15 of 44 swedish dissertations containing the word antiproliferative.

  2. 11. Class I Ribonucleotide Reductases : overall activity regulation, oligomerization, and drug targeting

    Author : Venkateswara Rao Jonna; Anders Hofer; Arne Holmgren; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; GEMMA; Allosteric regulation; medicinsk biokemi; Medical Biochemistry;

    Abstract : Ribonucleotide reductase (RNR) is a key enzyme in the de novo biosynthesis and homeostatic maintenance of all four DNA building blocks by being able to make deoxyribonucleotides from the corresponding ribonucleotides. It is important for the cell to control the production of a balanced supply of the dNTPs to minimize misincorporations in DNA. READ MORE

  4. 12. Synthetic studies on naphthoxylosides - labeled compounds and mechanistic studies on acetals

    Author : Richard Johnsson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Fluorescent xylosides; Carbohydrates; Naphthoxylosides; Cancer; Mechanistic studies; Radioactive xylosides; Acetals;

    Abstract : Labeled analogs to an antiproliferative naphthoxyloside have been synthesized and evaluated. Our investigations have shown that the fluorescently labeled analogs are poor structural analogs, and the physical and biological properties are altered to a large extent. READ MORE

  5. 13. Alkaline Sphingomyelinase; A Potential Inhibitor in Colorectal Carcinogenesis

    Author : Erik Hertervig; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Cytologi; cancerology; oncology; Cytology; Gastroenterologi; Gastro-enterology; HT-29; MIN mouse; FAP; colorectal cancer; human; alkaline sphingomyelinase;

    Abstract : Sphingomyelin (SM) is present both in eucaryotic cells and the diet. Sphingomyelinase (SMase) hydrolyses SM and generates ceramide that has been implicated in the regulation of cell growth, differentiation and apoptosis. Previously a SMase with alkaline pH optimum was identified in the intestinal tract. READ MORE

  6. 14. Naphthoxylosides Investigations into glycosaminoglycan biosynthesis

    Author : Mårten Jacobsson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organisk kemi; proteoglycan; Organic chemistry; nucleophilic aromatic substitution; thioether; glycosaminoglycan; xylosides; naphthoxylosides;

    Abstract : Glycosaminoglycans (GAGs) are members of a family of polysaccharide structures consisting mostly of repeating disaccharide units. Most GAGs are attached to specific serine residues in proteins to form proteoglycans (PGs). READ MORE

  7. 15. Role of estrogen receptor beta in mouse ventral prostate with relation to human prostatic diseases

    Author : Otabek Imamov; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In this thesis we investigate role of estrogen receptor beta (ERbeta) in development and functioning of mouse ventral prostate, using it as a model for human extrapolations. ERbeta was discovered in 1995 and is a member of a nuclear receptors superfamily, acting as a transcription factor for steroid hormone signaling. READ MORE