Search for dissertations about: "antiproliferative"

Showing result 16 - 20 of 44 swedish dissertations containing the word antiproliferative.

  2. 16. Exploring the genome-wide impact of estrogen receptor alpha and estrogen receptor beta in breast and colon cancer cells

    Author : Karin Edvardsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogen signaling is involved in the development and progression of breast cancer and is implicated to be protective in colon cancer. Estrogenic actions are conveyed through transcriptional regulation by ligand stimulated estrogen receptors (ERα and ERβ). READ MORE

  4. 17. Vitamin D Hydroxylating Enzymes and Analogues in Parathyroid Tumors and Breast Cancer

    Author : Ulrika Segersten; Gunnar Westin; Per Hellman; Göran Åkerström; Martin Bäckdahl; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; hyperparathyroidism; breast cancer; vitamin D; CYP27B1; CYP24A1; vitamin D analogues; ketoconazole; vitamin D receptor; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Abstract : In hyperparathyroidism (HPT) raised serum concentrations of ionized calcium is caused by increased secretion of parathyroid hormone (PTH) by parathyroid tumors. Active vitamin D, 1α,25-dihydroxyvitamin D3, is known to suppress PTH secretion and to reduce proliferation of parathyroid tumor cells. READ MORE

  5. 18. On the binding of growth-promoting polyamines to proteoglycans: Implications for growth-regulation and polycation-mediated gene transfer

    Author : Mattias Belting; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cationic lipid.; gene transfer; gene therapy; cell growth; polyamine transport; spermine; polyamine; growth-inhibition; heparan sulphate; dermatan sulphate; Proteoglycan; glycosaminoglycan; cytogenetics; Genetik; cytogenetik;

    Abstract : Initial investigations were directed at studying the interaction between polyamines and various glycosaminoglycans (GAGs). The polyamine spermine displayed binding to dermatan sulphate (DS) and heparan sulphate (HS) with similar (Kd, 3.9 x 10-4 M) and higher (Kd, 0.37 x 10-6 M) affinity, respectively, than to DNA. READ MORE

  6. 19. Studies on function and regulation of the transcription factor C/EBPalpha

    Author : Per Flodby; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The transcription factor C/EBPalpha was originally identified as a protein involved in hepatocyte-specific gene regulation. Later, it has been demonstrated that C/EBPalpha is expressed in several other tissues, mainly in adipose cells, lung, intestine, skin and in myeloid cells. READ MORE

  7. 20. Development of a targeted Drug Delivery System for treatment of Pancreatic Ductal Adenocarcinom

    Author : Carlos Urey; Lund Kirurgi; []
    Keywords : Drug Delivery Systems; Liposomes; Pancreatic cancer;

    Abstract : Pancreatic cancer is the fourth leading cause of cancer-related death with a 5-year survival of less than 6%. The only potential cure for pancreatic cancer is by surgical removal of the tumor. However, most patients present with an advanced and metastasized disease at the time of diagnosis, leaving only around 15% of patients eligible for surgery. READ MORE